Lecture #15 - Thiamine (B1)

Question 1

What is significant about Thiamine (B1)?

Answer 1

Thiamine was the first vitamin to be discovered.

Question 2

What disease is associated with Thiamine deficiency?

Answer 2

Beriberi, a disease resulting from Thiamine deficiency.

Question 3

What are the two basic sources of Thiamine?

Answer 3

Plants: free non-phosphorylated form

Animals: thiamine pyrophosphate in the phosphorylated form.

LOOK AT DOC FOR VISUAL REPRESENTATION OF THE TWO

Question 4

What destroys thiamine

Answer 4

Exposure to heat destroys thiamine, so cooking causes loss of the vitamin (there will still be some left over)

Question 5

What are the primary functions of Thiamine?

Answer 5

Important for energy transformation
synthesis of pentoses and NADPH
energy metabolism
activates chloride transport in nerve membranes involved in nerve impulse transmission.