Lecture 13 (Part 2) - Metabolism of VLDL Flashcards
What is the primary function of VLDL in the body, and where are they primarily synthesized?
VLDL delivers endogenously generated lipids from the liver to peripheral tissues and gives rise to LDL. They are primarily synthesized in the liver.
What is the precursor form of VLDL, and where does it originate from?
Nascent VLDL originates from the liver.
What additional apoproteins do VLDL acquire before interacting with peripheral tissues?
VLDL acquires additional ApoCII and ApoE.
What is the fate of VLDL after it delivers its triglyceride content to tissues?
VLDL shrinks in size and becomes IDL (intermediate-density lipoprotein).
Describe the interaction between IDL and HDL during lipid metabolism.
IDL interacts with HDL and gives back ApoE.
Where are LDL receptors found, and what is their role in lipid metabolism?
LDL receptors are found in all tissues, including the liver. They interact with LDL particles and facilitate the donation of cholesterol to peripheral tissues.
What is the main function of LDL in the body?
deliver cholesterol to peripheral tissues.
Why is LDL often referred to as “bad cholesterol”?
LDL is often associated with the accumulation of plaque on arterial walls, which can lead to heart disease.
What dietary factor can increase VLDL production in the liver?
A diet rich in sugar, particularly fructose, can increase VLDL production in the liver.
