Lecture 40 - Schizophrenia and Antidepressants

Question 1

Positive symptoms?

Answer 1

delusions, auditory hallucinations

Question 2

Negative symptoms?

Answer 2

withdrawal, flattened mood

Question 3

Dopamine theory?

Answer 3

schizophrenia occurs due to over-stimulation of dopamine in ventro-limbic and cortical arwas

Question 4

Evidence of dopamine theory?

Answer 4

meth raises dopamine and has psychotic symptoms. and it is known that anti-psychotics are successful through blocking dopamine receptors

Question 5

Evidence for glutamate theory?

Answer 5

PCP blocks NMDA causing both negative and positive symptoms

Question 6

DA antagonists?

Answer 6

chlorpromazine and haloperidol - mainly work on positive symptoms

Question 7

Negative symptom drug?

Answer 7

Clozapine

Question 8

D receptor types?

Answer 8

D1 and 5 are Gs, D2 3 4 are Gi

Question 9

Unipolar depression>

Answer 9

mood appetite negative self concept; endogenous or reactive

Question 10

Bipolar manic depression?

Answer 10

fluctuation between depression and mania

Question 11

Tricyclic antidepressant?

Answer 11

amitriptyline

Question 12

MAO inhibitor?

Answer 12

phenelzine

Question 13

SSRI?

Answer 13

fluoxetine

Question 14

Manic depression treatment?

Answer 14

lithium carbonate

Question 15

Depression and neurogenesis?

Answer 15

lithium promotes neurogenesis, other antidepressants also promote, stress reduces