Lecture 13 - Basal Ganglia

Question 1

Extreme capsule function?

Answer 1

seperate neo cortex from basal ganglia

Question 2

Striatum consists of?

Answer 2

caudate nucleus & putamen

Question 3

Direct pathway?

Answer 3

cortex (+) striatum (-) internal globus pallidus (-) vavl thalamus (+) cortex

Question 4

Indirect pathway?

Answer 4

cortex (+) striatum (-) external globus pallidus (-) sub-thalamic nucleus (+) internal globus pallidus (-) vavl thalamus (+) cortex

Question 5

Parkinson’s symptoms?

Answer 5

flat mood, bradykinesia, tremoe, rigidity

Question 6

Parkinson’s pathology?

Answer 6

loss of DA cells in substantia nigra pars compacta, leading to DA depletion in striatum

Question 7

Parkinson’s treatment?

Answer 7

L-dopa, stem cell transplant, gene therapy

Question 8

Parkinson’s surgery?

Answer 8

pallidotomy (GP), thalanotomy, DBS

Question 9

Huntington’s symptoms?

Answer 9

behavioural/cognitive differences, hyperkinesia, involuntary movements

Question 10

Pathology of Huntington’s?

Answer 10

loss of GABA neurons in striatum