Lecture 29 - Parkinson's Clinical Flashcards
1
Q
Diagnosis requirements?
A
2 of: rest tremor, bradykinesia, rigidity, postural abnormalities
2
Q
Non-motor symptoms?
A
constipation, pain, sleep disturbance, depression, dementia
3
Q
Pathology?
A
degeneration of dopaminergic neurons in the substantia nigra, contain Lewy bodies, decreased innervation of basal ganglia and cortex
4
Q
Pathogensis?
A
unknown: genetic susceptibility, toxins (MPTP-Parkinsonism, encephalitis lethargica
5
Q
Drug treatments?
A
Levadopa, DA agonists, anticholinergics, MOAB inhibs, COMT inhibs
6
Q
Surgical treatment?
A
thalamotomy, pallidotomy, stem cell transplant, deep brain stimulation
7
Q
Late complications?
A
congitive deficit, emotional disturbance, fluctuations, postural hypotension
