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Therapeutics > Lecture 3 Exam 5 > Flashcards

Lecture 3 Exam 5 Flashcards

1
Q

Estrogen (ethnyl estradiol) effect of FSH

A

suppresses FSH production, prevents dominant follicle and ovulation

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2
Q

Effect of estrogen (ethnyl estradiol) on sex hormone binding globulin

A

Increases sex hormone binding globulin and increases binding of free androgens

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3
Q

How does ethnyl estradiol improve acne

A

It increase binding of free androgens

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4
Q

how does progestin inhibit ovulation

A

prevents LH surge

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5
Q

effect of progestin on cervical mucus

A

thickens mucus (inhibits sperm penetration)

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6
Q

Effect of progestin on motility of fallopian tube

A

(impair sperm/ova transport)

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7
Q

effect of progestin on endometrium

A

impairs implantation

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8
Q

3 components of progestin

A

progestational
androgenic
antiestrogenic

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9
Q

progestational effects of progestin

A

prevents ovulation
lessens bleeding
desire high activity

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10
Q

androgenic effects of progestin

A

acne
hirsutism
desire low activity

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11
Q

antiestrogenic effects of progestin

A

androgenic side effects
desire lower activity.0

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12
Q

highest androgenic activity drug

A

levonorgestrel

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13
Q

highest progestational activity drug

A

levonorgestrel
desogestrel/etonogestrel

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14
Q

What are some signs of not enough progestin

A

breakthrough bleeding late in the cycle
no withdrawal bleeding
heavy menses

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15
Q

signs of too much progestin

A

acne
hirsutism
decreased sex
depression
increased appetite
increased sex drive
weight gain
less energy

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16
Q

Common side effects of progestin

A

Acne worsening
hair growth in weird places
heavier periods

17
Q

drug name
Efficacy
hormone type
ROA
side effects
return of fertility

Of the Implant (nexplanon)

A

Nexplanon
>99% efficacy
only progestin
left in non-dominant arm for 3 years if inserted >5 days after start of period, use backup method for 7 days
side effects include- Acne, h/a, mood changes, bleeding
fertility returns within 6 weeks

18
Q

drug name
Efficacy
hormone type
ROA
side effects
return of fertility

of levonorgestrel IUD

A

99% efficacy
progestin only
left for 3-7 years
use backup method for 7 days after inseertion
side effects- uterine perforation, expulsion, infection

19
Q

Efficacy
hormone type
ROA
side effects
return of fertility

of depot medroxyprogesterone

A

94%
progestin only
15 weeks
weight gain, acne
delayed return of fertility

20
Q

serious side effects of COC

A

blood clots(estrogen related)

21
Q

What are some progestin only pills

A

Norethindrone (minipill)
Drosperinone

22
Q

Timing for norethindrone (mini pill)

A

within 3 hours everyday

23
Q

how long does it take for the mini pill to be effective

A

48 hours

24
Q

What to do for the minipill if more than 3 hours late

A

take ASAP and use backup for 2 days

25
Q

What to do if late for dose for COC

A

if 1 pill- take asap
of 2 pills- take asap and next pill at usual time, use back up contraceptive for 7 days

26
Q

is minipill safe to breast feed?

A

yes

27
Q

return to fertility for minipill

A

Immediate

28
Q

number of placebo pills in norethindrone (minipill) vs drosperinone (slynD)

A

0 for mini
4 for drosperinone

29
Q

how long should backup be used for drosperinone and COC if started more than 5 days after period

A

7 days

30
Q

Name drugs for the monthly and annual vaginal ring. Difference is administration? hormone content?

A

annual- annovera
monthly- nuvaring, eluring
annual- left in place for 3 weeks and removed for 1, wash, reinsert
monthly- 3 weeks and removed 1 week.

both are progestin+estrogen

31
Q

what to do for the rings if removed for more than 3 hours

A

reinsert and use backup for 7 days

32
Q

What to do if ring was in for 3 weeks but less that 4 weeks

A

remove ring, put new ring in 7 days later

33
Q

What to do if ring was in for more than 4 weeks

A

Put in new ring immediately and use backup for 7 days

34
Q

Name 2 patch drugs
hormone type
strength
How to apply

A

Xulane, Zafemy
progestin & Estrogen

35 mcg estrogen/day (HIGH)
Put on a new patch every week for 3 weeks, 1 week no patch

35
Q

What to do if patch was on for more than 9 dayys and off for 24 hrs

A

apply new patch and use backup for 7 days

36
Q

serious side effects of patch? why?

A

blood clots, due to more estrogen

37
Q

how many mcg of estrogen does the patch TWIRLA have

A

30 mcg (less than other patches)

38
Q

Serious side effects of estrogen

A

ACHES
Abdominal pain
chest pain
headache
eye problems
swelling

Therapeutics (46 decks)

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