final exam lecture 5 Flashcards

1
Q

Increase in intestinal motility leads to_____. Decrease un intestinal motility leads to_____

A

diarrhea, constipation

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2
Q

relationship between segmenting contractions and diarrhea

A

patients with diarrhea often have fewer spontaneous segmenting contractions

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3
Q

classifications of diarrhea

A

Acute, persistent, chronic, chronic idiopathic

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4
Q

difference between acute, persistent, chronic and chronic idiopathic

A

acute diarrhea <14 days (usually caused by infectious process)
persistent >14 days
chronic >30 days
chronic idiopathic >or equal to 4 weeks (persistently loose stool without identifiable cause)

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5
Q

chronic diarrheaaffects what percent of people

A

5%

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6
Q

most common foodborne cause of diarrhea and vomiting

A

Norovirus

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7
Q

What is fecal incontinence

A

Inability to control bowel movements, causing stool to leak unexpectadely

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8
Q

4 ways to classify diarrhea

A

Secretory
osmotic
exudative
altered intestinal transit

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9
Q

Secretory diarrhea mechanism? what does it cause?

A

Change in active ion transport causes water to move into the intestine. Causes large stool volumes (>1L/day). It does not improve with fasting

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10
Q

how is osmotic diarrhea caused? What does it cause?

A

It is caused when poorly absorbed substances are retained in intestinal fluids; resulting in influx of water. Causes lactose intolerance. Improves with fasting.

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11
Q

Exudative diarrhea define

A

Subset of diarrhea. secondary to inflammatory disease of the bowel. We see mucus, protein and blood in gut.

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12
Q

3 infectious organisms commonly associated with causing diarrhea

A

Bacteria (salmonella) most common bacteria in US), viral
viral- norovirus/ rota virus

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13
Q

common medications for drug induced diarrgea

A

Laxatives, metformin etc

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14
Q

complications of diarrhea

A

dehydration
electrolyte imbalance

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15
Q

evaluating a patient for dehydration

A

skin tenting, concentrated urine, dizziness when standing, dry mucous membrane

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16
Q

questions to ask patients regarding their diarrhea

A

When did symptoms begin
Frequency, consistency and color of stool
abdominal pain?
recent travel?

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17
Q

non pharmacologic treatment for diarrhea. What kind of diarrhea is it more important for?

A

BRAT diet (banana, rice, apple sauce, toast)
more important foo osmotic diarrhea

fluid- electrolyte replacement

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18
Q

Treatment if acute diarrhea (<3 days) with no fever or systemic symptoms

A

Symptomatic therapy
1) fluid/electrolyte
2) loperamide, diphenoxylate
3) diet

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19
Q

How to treat acute diarrhea with fever or systemic symptoms

A

Check feces for WBC/RBC/Ova and parasites.
If negative- symptomatic therapy.
If positive- use appropriate antibiotic therapy

20
Q

treatment of chronic diarrhea

A

Always refer to physician
Give hydration and loperamide

21
Q

how to prevent travelers diarrhea

A

drink bottled water
antimicrobial prophylaxis should not be used routinely

22
Q

medicine to prevent travelers diarrhea

A

Bismuth subsalicylate

23
Q

When is the only time we can use antimicrobial prophylaxis to treat travelers diarrhea? What antibiotic is recommended

A

Rifaximin is recommended. Only used for at risk populations.

24
Q

Treatment for mild travelers diarrhea

A

Oral rehydration is used on ALL patients with travelers diarrhea.
Antibiotic use is not recommended
Loperamide or BSS may be considered
BSS dose: 60 ml or 2 tabs QID

25
Moderate travelers diarrhea treatment
Antibiotic MAY be used. Loperamide may be considered as monotherapy or adjunctive
26
Travelers diarrhea (severe)
Antibiotic treatment SHOULD be used. Single dose therapy preferred. Loperamide may be used as adjunctive therapy
27
How to treat drug induced diarrhea
Dx offending agent and use oral rehydration agents.
28
how do antimotility drugs treat diarrhea
They activate Mu opioid receptors on smooth muscle of the bowel to reduce peristalsis and increase segmentation
29
What are some concerns with antimotility drugs? name an antimotility drug
Should not be used long term and Not to be used with C.diff diarrhea. Loperamide
30
loperamide doses
4 mg initially with 2 mg after each loose stool. Do not exceed 16 mg/day
31
how do anti secretory drugs treat diarrhea
act by reducing secretions in gut.
32
name an expample of antisecretory drugs
BSS (bismuth sub salicylate) (pepto bismol)
33
dosing of peptobismol? side effects?
2 tabs (30 ml) every 30-60 mins prn (upto 8 doses/24 hrs) may potentiate anticoagulants, cause stools to turn black
34
Name 4 antimotility drugs. Maxdosing? OTC or RX? controlled sybstance?
Loperamide- do not exceed 8 pills a day, OTC diphenoxylate/atropine (lomotil)- do not exceed 20 mg/day (4 pills), C V (RX ONLY) Difenoxin/Atropine (motofen)- Not to exceed 8 tabs a day (CIV) Rx only1
35
Name an absorbent. DIarrhea or constipation? DOsing?
Psyllium (metamucil), 1-2 tsp mixed in 8 oz water 1-3 times a day
36
name some causes of constipation
Dietary (Poor fluid intake, decreased caloric intake) Disease states that slow down GI motility (diabetes, Parkinsons, CNS injury)
37
Common drugs that cause constipation
Opioids (mu receptor antagonists) NSAIDs (much less extent than opioids) Antacids Iron preparations
38
When to refer patients with constipation?
Sx persist longer than 2 Weeks Fever black tarry stools marked abd pain/discomfort Severe nausea/vomiting Family history of IBD or colon cancer
39
Measures to help promote regular bowel habits
6-8 glasses of water a day Add fiber to diet slowly (increase over 7-10 days) Prunes
40
Moa of bulk laxatives
Forms emollient gels which retain water, swell and stimulate BM
41
Bulk laxative drugs
Psyllium- metamucil Methylcellulose- citrucel (will not cause gas) Calcium polycarbophil- fibercon
42
Advantage vs disadvantage of bulk laxatives
Advantage- Softens the stools better than docusate Disadvantage- gas formation, impact on drug absorption
43
MOA of hyperosmotic agents
Draws fluid into colon due to hugh cone=centration of sugar.
44
Examples of Hyperosmotic drugs
MiraLAX, PEG
45
Adv vs Disadv of hyperosmotic agents
EXCELLENT FOR CHRONIC CONSTIPATION disadv- 1-3 day onset
46
Dose of miralax
17 g po daily