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Microbiology - Biol3880 > Lecture 21 - Immunity (acquired) > Flashcards

Lecture 21 - Immunity (acquired) Flashcards

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1
Q

what are required for activation of the adaptive immune response?

A

Cytokines produced by innate response

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2
Q

T cells can recognize antigen only when presented on self proteins called ____________

A

major histocompatibility complex (MHC) proteins

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3
Q

T-cell activation is restricted both by _______ and by ________

A

antigen and MHC

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4
Q

what Presents to the CD8 T-cells

A

MHC Class I

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5
Q

what Presents to CD4 T-cells

A

MHC Class 2

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6
Q

Recognize antigen presented by MHC I protein on an infected cell

A

T-cytotoxic cells (T-cells)

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7
Q

Activates killing response in phagocytic cells

A

TH1

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8
Q

Activates plasma cell differentiation in response antibody-bound antigen

A

TH2

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9
Q

Effective at killing intracellular pathogens that are phagosome-bound

A

TH1

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10
Q

Induces production of antibody

A

TH2

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11
Q

Stimulates innate response

A

TH1

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12
Q

Stimulates acquired response

A

TH2

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13
Q

are soluble proteins made by B cells in response to exposure to nonself antigens

A

antibodies (immunoglobulins)

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14
Q

antigens are primarily short _______

A

peptides

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15
Q

what are the 4 sources of antibody diversity?

A

1) multiple coding sequencing segments encoded in genome
2) coding segments that can be combined
3) Variable spacing and recombination can add or delete nucleotides
4) somatic hypermutation

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16
Q

this source of antibody diversity Occurs after antigen presentation to naïve B-cells

A

somatic hypermutation

17
Q

which antibody isotype is Found largely on mucosal surfaces

A

IgA

18
Q

which antibody isotype is Found on immature B-cells

A

IgD

19
Q

which antibody isotype Binds antigens and stimulates release of histamines from mast cells

A

IgE

20
Q

which antibody isotype is Effective against parasitic worms

A

IgE

21
Q

which antibody isotype is responsible for allergies?

A

IgE

22
Q

which antibody isotype is The central antibody of antibody-based immunity

A

IgG

23
Q

which antibody isotype is a Strong activator of opsonization and complement

A

IgG

24
Q

Principle isotype in blood and extracellular fluid

A

IgG

25
Q

which antibody isotype is responsible for clearing out pathogens in your body?

A

IgG

26
Q

which antibody isotype is Produced before somatic hypermutation

A

IgM

27
Q

First isotype expressed in acquired response

A

IgM

28
Q

antibody isotope that Can form pentamers to effectively bind large, multi-valent antigens

A

IgM

29
Q

which antibody isotope cannot leave the bloodstream?

A

IgM

30
Q

which antibody isotope is responsible for A/B blood typing?

A

IgM

Microbiology - Biol3880 (23 decks)

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