Lecture 21 - Immunity (acquired) Flashcards
what are required for activation of the adaptive immune response?
Cytokines produced by innate response
T cells can recognize antigen only when presented on self proteins called ____________
major histocompatibility complex (MHC) proteins
T-cell activation is restricted both by _______ and by ________
antigen and MHC
what Presents to the CD8 T-cells
MHC Class I
what Presents to CD4 T-cells
MHC Class 2
Recognize antigen presented by MHC I protein on an infected cell
T-cytotoxic cells (T-cells)
Activates killing response in phagocytic cells
TH1
Activates plasma cell differentiation in response antibody-bound antigen
TH2
Effective at killing intracellular pathogens that are phagosome-bound
TH1
Induces production of antibody
TH2
Stimulates innate response
TH1
Stimulates acquired response
TH2
are soluble proteins made by B cells in response to exposure to nonself antigens
antibodies (immunoglobulins)
antigens are primarily short _______
peptides
what are the 4 sources of antibody diversity?
1) multiple coding sequencing segments encoded in genome
2) coding segments that can be combined
3) Variable spacing and recombination can add or delete nucleotides
4) somatic hypermutation
this source of antibody diversity Occurs after antigen presentation to naïve B-cells
somatic hypermutation
which antibody isotype is Found largely on mucosal surfaces
IgA
which antibody isotype is Found on immature B-cells
IgD
which antibody isotype Binds antigens and stimulates release of histamines from mast cells
IgE
which antibody isotype is Effective against parasitic worms
IgE
which antibody isotype is responsible for allergies?
IgE
which antibody isotype is The central antibody of antibody-based immunity
IgG
which antibody isotype is a Strong activator of opsonization and complement
IgG
Principle isotype in blood and extracellular fluid
IgG
which antibody isotype is responsible for clearing out pathogens in your body?
IgG
which antibody isotype is Produced before somatic hypermutation
IgM
First isotype expressed in acquired response
IgM
antibody isotope that Can form pentamers to effectively bind large, multi-valent antigens
IgM
which antibody isotope cannot leave the bloodstream?
IgM
which antibody isotope is responsible for A/B blood typing?
IgM
