Lec 30 Flashcards
why Na and water are important
ECF volume and osmolarity
why k is important
cardiac and muscle function
why Ca is important
exocytosis, muscle contraction, bone formation
why h and hco3 are important
ph balance
body must maintain
mass balance
input + cellular respiration = cellular consumption + excretion
excretion route is via
kidney
what come in body in excess of needs musy
excrete
fluid and electrolyte balance involve
integration of respiratory, renal, cardiovascular system
most abundant compound of body
water
water gain by
food and drink
metabolism
water loss by
skin
lungs
urine
feces
water in male
30 L
water in female
42 L
kidney remove or conserve body fluid b y
regulate amount of H2O reabsorb
final osmolarity of urine depend on
hormona regualtion of H2O reabsorption in distal nephron
descending limp absorbtion
water
ascending limb absorption
ions but no water
creating hyposmotic fluid
distal tubule reabsorption
variable water and solutes
collecting duct reabsorption
water by aquaporin/vasopressin
vassopressin (ADH) is
neurohormone
ADH released by
posterior pituitary gland
stimuli for ADH release
1- high plasma osmolarity
2- low blood volume
3- low blood pressure
ADH control
additon of water poles (aquaporines) into apical membrane of collecting duct
result ADH
increased water reabsorption
more concentrated urine
response may be — and depend on amount of hormone released
graded
low BP
1- sense by carotid and aortic baroreceptors
2- sensory to hypothalamus
3- hypothalamic neuron synthesize ADH
4- ADH release from posterior pituitary
5- collecting duct epithelium
6- insertion water pores
7- increased water reabsorption
low blood volume
1- decrease arterial stretch
2- arterial stretch receptor
3- sensory to hypothalamus
3- hypothalamic neuron synthesize ADH
4- ADH release from posterior pituitary
5- collecting duct epithelium
6- insertion water pores
7- increased water reabsorption
high osmolarity
1- hypothalamic osmoreceptors
2- interneurons to hypothalamus
3- hypothalamic neuron synthesize ADH
4- ADH release from posterior pituitary
5- collecting duct epithelium
6- insertion water pores
7- increased water reabsorption
ADH production has – feedback
negative
Aldosterone regulate
Na reabsorption
Aldosterone properties:
1- steroid hormone
2- synthesis and released from adrenal cortex
3- act on principal cells of distal tubule and collecting duct
stimuli aldosterone release
1- angiotensin II (low BP and RAS)
2- hyperkalemia (high K in plasma)
aldosterone result
1- Na reabsorption
2- K secretion
very high osmolarity has — impact on adrenal cortex aldosterone release
negative