Lec 10-11 Flashcards
CNS
Brain/spinal cord
Brain protect by
Bones of cranium
Spinal cord protect by
Bones of vertebral column
Meninges
Tissue membrane
Stabilize and protect neural tissue
Lie between bones and brain/spinal cord
Meninges parts from out to in
1- Dura meter
2- Arachnoid membrane
3- Pia meter
Ventricles of brain
4 ventricles
-within ventricles CSF produce
Functions of CSF
1- Physical Protection
——keeps brain tissue buoyant(reduce pressure)
——absorbs shock
2- Chemical Protection
——delivering nutrients to the brain
——removing waste
——allow tightly regulated extracellular environment
CSF is produced in
Choroid Plexus of ventricles
Choroid plexus
-Meeting of capillaries and ependymal cells
-Plasma filtered into ventricles
-Ependymal cells selectively transport solutes, water flow by osmosis
-transport ions and nutrients from blood to cerebrospinal fluid
CSF composition
Similar chemical composition to plasma but
——very low protein content in CSF
CSF is absorbed from subarachnoid space into venous circulation by——
Arachnoid villi
Total volume of CSF in adult
150 ml
-rate of secretion and absorption is equal
Subarachnoid space
Filled with CSF
Tight junction
Prevent moving larger solutes between endothelial cells
Astrocyte foot processes
Secrete paracrine onto endothelial cells that promote tight junction formation
Blood-Brain-Barrier
Blood-brain is leaky without astrocytes
Tight junction are caused by paracrine which is produced by astrocyte
Metabolic needs of neural tissue
1- Oxygen:
——pass freely across BBB
2- Glucose:
——need transporters - trancellularly
——only replacement is ketone——emergency situations
——brain consumption is about 20% of body total amount
——hypoglycemia leads to confusion
Gray matter
Nucleus
Dendrite/synapses
Deep inside or peripheral in BRAIN