Lec 27

Question 1

at equilibrium, partial pressure above and in solution are

Answer 1

equal

Question 2

at equilibrium, concentration above and in solution are

Answer 2

not equal

Question 3

CO2 is – more soluble than O2

Answer 3

20x

Question 4

capacity of plasma for CO2 is

Answer 4

very low

Question 5

total O2 in blood

Answer 5

dissolved in plasma + bound to hemoglobin

Question 6

Hb bound to O2 is

Answer 6

Oxyhemoglobin

Question 7

plasma carry – ml O2/L blood

Answer 7

3 ml

Question 8

Hb carry – ml O2/L blood

Answer 8

197 ml
98% of total maximum load of oxygen

Question 9

why O2-Hb dissociation curve is sigmoidal

Answer 9

cooperation
binding of the oxygen, increases binding affinity of the remaining sites

Question 10

P o2 in tissues

Answer 10

0-40 mmHg

Question 11

P O2 in alungs

Answer 11

60-100 mmHg

Question 12

When P O2 is high, Hb is

Answer 12

saturated

Question 13

highest saturation Hb is in

Answer 13

alveoli

Question 14

why if Hb wasn’t wrking cooperatively

Answer 14

in tissues we should have gone to very small concentrations of O2 to be able to drop off oxygen

Question 15

higher P50 of Hb saturation means

Answer 15

1-higher conc. of O2 required
2-affinity of O2 decreased

Question 16

effect of pH on oxygen binding to Hb

Answer 16

lower pH
-reduce carrying capacity Hb
–more O2 dissociate as tissues need more
—p50 increases
—-when skeletal muscle activity is high happenes

Question 17

effect of P CO2 on oxygen binding to Hb

Answer 17

higher P CO2
-body need more O2
–drop off O2 increase
—Hb affinity for O2 decrease
—-P50 increase

Question 18

O2 transport in blood (lung)

Answer 18

O2 diffuse to plasma
due to high P O2 in plasma drives O2 binding to Hb

Question 19

O2 transportt in blood (tissue)

Answer 19

O2 diffuse out to tissue
due to low p O2 in plasma derive O2 dissociation from Hb

Question 20

CO2 transport in blood

Answer 20

1-7% dissolved in plasma
2-23% transport as HbCO2
3-70% transport as bicarbonate

Question 21

CO2 binding to Hb

Answer 21

CO2 can bind to any group on Hb

Question 22

bicarbonate formula and enzyme

Answer 22

CO2 + H2O –> H2CO3 –> H+ + HCO3-
enzyme: carbonic anhydrase

Question 23

bicarbonate is an important —- in the body

Answer 23

buffer

Question 24

CO2 binded Hb name

Answer 24

carbaminohemoglobin

Question 25

CO2 transport near tissue

Answer 25

CO2 diffuse to plasma
major CO2 conc. will diffuse to blood
-23% bind with Hb
–70% react with water produce bicarbonate and H+
—bicarbonate will exchange with Cl- to enter plasma
—-H+ will buffered by Hb

Question 26

CO2 transport near lung

Answer 26

CO2 diffuse to alveoli
-dure to low plasma CO2, CO2 will disociate first from Hb then from bicarbonate

Question 27

sensory receptors convert chemical signal to

Answer 27

action potential

Question 28

central chemoreceptors are located in

Answer 28

medulla

Question 29

Chemoreceptors increase activity in response to

Answer 29

increased PCO2

Question 30

central Chemoreceptors result after detecting high PCO2

Answer 30

increase rate and depth of respiration

Question 31

peripheral chemoreceptors are located in

Answer 31

aortic arch and carotid sinuses

Question 32

peripheral chemoreceptors increase activity in response to

Answer 32

high PCO2
low pH
low PO2

Question 33

periphery Chemoreceptors result after detecting high PCO2

Answer 33

affrent signal to medulla
increase rate and depth of respiration