Lec 27 Flashcards

1
Q

at equilibrium, partial pressure above and in solution are

A

equal

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2
Q

at equilibrium, concentration above and in solution are

A

not equal

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3
Q

CO2 is – more soluble than O2

A

20x

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4
Q

capacity of plasma for CO2 is

A

very low

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5
Q

total O2 in blood

A

dissolved in plasma + bound to hemoglobin

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6
Q

Hb bound to O2 is

A

Oxyhemoglobin

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7
Q

plasma carry – ml O2/L blood

A

3 ml

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8
Q

Hb carry – ml O2/L blood

A

197 ml
98% of total maximum load of oxygen

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9
Q

why O2-Hb dissociation curve is sigmoidal

A

cooperation
binding of the oxygen, increases binding affinity of the remaining sites

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10
Q

P o2 in tissues

A

0-40 mmHg

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11
Q

P O2 in alungs

A

60-100 mmHg

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12
Q

When P O2 is high, Hb is

A

saturated

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13
Q

highest saturation Hb is in

A

alveoli

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14
Q

why if Hb wasn’t wrking cooperatively

A

in tissues we should have gone to very small concentrations of O2 to be able to drop off oxygen

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15
Q

higher P50 of Hb saturation means

A

1-higher conc. of O2 required
2-affinity of O2 decreased

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16
Q

effect of pH on oxygen binding to Hb

A

lower pH
-reduce carrying capacity Hb
–more O2 dissociate as tissues need more
—p50 increases
—-when skeletal muscle activity is high happenes

17
Q

effect of P CO2 on oxygen binding to Hb

A

higher P CO2
-body need more O2
–drop off O2 increase
—Hb affinity for O2 decrease
—-P50 increase

18
Q

O2 transport in blood (lung)

A

O2 diffuse to plasma
due to high P O2 in plasma drives O2 binding to Hb

19
Q

O2 transportt in blood (tissue)

A

O2 diffuse out to tissue
due to low p O2 in plasma derive O2 dissociation from Hb

20
Q

CO2 transport in blood

A

1-7% dissolved in plasma
2-23% transport as HbCO2
3-70% transport as bicarbonate

21
Q

CO2 binding to Hb

A

CO2 can bind to any group on Hb

22
Q

bicarbonate formula and enzyme

A

CO2 + H2O –> H2CO3 –> H+ + HCO3-
enzyme: carbonic anhydrase

23
Q

bicarbonate is an important —- in the body

24
Q

CO2 binded Hb name

A

carbaminohemoglobin

25
CO2 transport near tissue
CO2 diffuse to plasma major CO2 conc. will diffuse to blood -23% bind with Hb --70% react with water produce bicarbonate and H+ ---bicarbonate will exchange with Cl- to enter plasma ----H+ will buffered by Hb
26
CO2 transport near lung
CO2 diffuse to alveoli -dure to low plasma CO2, CO2 will disociate first from Hb then from bicarbonate
27
sensory receptors convert chemical signal to
action potential
28
central chemoreceptors are located in
medulla
29
Chemoreceptors increase activity in response to
increased PCO2
30
central Chemoreceptors result after detecting high PCO2
increase rate and depth of respiration
31
peripheral chemoreceptors are located in
aortic arch and carotid sinuses
32
peripheral chemoreceptors increase activity in response to
high PCO2 low pH low PO2
33
periphery Chemoreceptors result after detecting high PCO2
affrent signal to medulla increase rate and depth of respiration