Laboratory animal science

Question 1

What major purposes are animals used for in scientific experiments?

Answer 1

drug research, vaccine testing, toxicity testing, cancer research.
Other purposes: biomedical research, genetic studies, diagnosis, experimental surgery, education.

Question 2

What are basic methodical approaches in Physiology?

Answer 2

Experience/observation
Dissection/autopsy
Clinical study (adspection, palpation, auscultation, percussion)
Experiment (in vivo, ex vivo, in vitro, in ovo, in silico)
Modelling (observation, verification, computers, mathematics, living models/model organisms)

Question 3

Alternatives to animal experiments?

Answer 3

in vitro, ex vivo techniques
use of lower organisms
immunological techniques
quantitative structure-activated relationship analysis
mathematic modelling of processes
human models
video/computer based demonstrations

Question 4

What is the 3R Principle and who introduced it, which year?

Answer 4

Replacement, Reduction, Refinement –> main guideline for the responsible use of animal in experiments.
Introduced by Russel and Burch in 1958

Question 5

What is the meaning of the 3R Principle?

Answer 5

Replacement: substitution of living animals by alternative technique
Reduction: decrease in the number of animals required in a given experiment
Refinement: Decrease in the incidence or severity of painful or distressing procedures applied to animals.

Question 6

What is FELASA and when was it established?

Answer 6

Federation of labotatory animal science association.
1978.
To advocate responsible scientific conduct with animals, ensuring animal welfare. It has relations with council of Europe, the european commission and european parliament.

Question 7

What is GLP principles?

Answer 7

Good Laboratory Practice.

Refers to the methods of conduct, management of the research and the circumstances which it is carried out.

Question 8

Name two important documents issued in Europe to create the basis for controllin the use of animals in experiments?

Answer 8

Convention for the protection of vertebrate animals used for experiments and other scientific purposes.

Directives for the protection of vertebrate animals used for experiments and other scientific purposes.