Functions of plasma proteins. Flashcards
What are plasma proteins?
Organic components of blood plasma, include albumines, globulines and fibrinogens
What is the function of plasma proteins?
transport, storage, coagulation factors, antibodies
What does plasma proteins contribute to?
oncotic pressure and suspension stability of the blood
What is blood serum?
Blood plasma without fibrin/fibrinogen
Name one method for detection and separation of plasma proteins?
Electrophoresis of blood serum or plasma –> result is electrophorogram.
What is electrophoresis?
Charged particles’ ability of migration in an electric field depending on size, surface charge, configuration, concentration.
What is electrophorese used for?
Simple protein separation, a screening method to evaluate organic components of blood plasma
What is CRP?
C-reactive protein is an acute phase protein which increase following macrofages and T-lymphocytes. Innflammation marker.
What are serpins?
Serine protease inhibitors. Superfamily of proteins which is related to coagulation and innflammation. Diagnostic marker of innflammation.
Pre-albumin?
Protein status assesment, nutrition marker, transport thyroid hormones.
Albumin
Maintenance of oncotic pressure, storage protein. Makes up half of serum proteins.
AGP (alpha acid-1 glycoprotein)?
Acute phase protein. Positive –> concentration increase in respond to tissue injury, innflammation or infection.
a-1 antitrypsin
serum trypsin inhibitor. Belongs to serpin family. Acute phase protein, conc. increase with acute innflammation. Absence –>neutrophils breaks down elastin, liver, lungs …
a-2 Haptoglobin
Binding free hemoglobin, prevents loss of iron and sunsequent kidney damage. Positive acute phase protein involved in angiogenesis and host defence.
a-2 Macroglobuline
largest major nonimmunoglubulin. Antiprotease inhibition of fibrinolysis by inhibiting plasmin ans kalkrein. Inhibitor of coagulation by inhibition of
thrombin. Transporter of growth factors and cytokines. Synthesized by liver.