Internal environment - acid base status Flashcards
How is acid/base balance established in an organism?
If the production and uptake of H+ protons corresponds to it’s consumption and elimination on the other side.
How is examination of acid-base status important?
For diagnostics of internal environment disorders and several organ or systemic failures.
What are major AB parameters?
pH, HCO3-, BE, pCO2
What are rules of pre-analytic handling of samples?
anaerobic collection, minimal compression, storage at 1.4C, analysis no later than 2 hrs.
Important to use venous blood from a central vein –> to receive information from the tissue.
Name some proton producing reactions?
non-oxidative glycolysis, ketogenesis, urea synthesis, lipolysis
Name some proton consuming reactions?
gluconeogenesis, lactate oxidation.
What are the sources of protons?
Tissue respiration, acid production during metabolism of proteins and phospholipids. (H3PO4, H2SO4, uric acid)
Which organs helps with the regulatory function of proton homeostasis?
lungs, kidney, bone and liver
What is the overall parameter of acid base balance?
pH
What is respiratory component assasment?
pCO2
What is metabolic component assasment?
HCO3, BE
What parameter does temperature effect?
Partial pressure of gasses. (calibration by 37 C)
What happens when there is compensation?
Parameters are trying to shift pH to the opposite side.
