Intracellular Accumulations

Question 1

accumulation of cholesterol within arterial walls ?

Answer 1

atheroma

Question 2

Macrophages phagocytose the lipid of necrotic cells ?

Answer 2

foam cells

Question 3

Albinism: This is generalized hypopigmentation due to ?

Answer 3

deficiency of tyrosinase

Question 4

“wear and tear pigment” or aging pigment is ?

Answer 4

Lipofuscin (Lipochrome) Pigments

Question 5

increased in cases of JAUNDICE ?

Answer 5

Bilirubin

Question 6

is a hemoglobin-derived iron containing pigment that is golden yellow to brown ?

Answer 6

Haemosiderin

Question 7

It is pathological excess of haemosiderin deposits in the tissues ?

Answer 7

Haemosiderosis

Question 8

calcium salts in dead or dying (degenerated) tissues. This type occurs with normal blood calcium level ?

Answer 8

DYSTROPHIC CALCIFICATION

Question 9

consisting of aggregated needle-shaped urate crystals ?

Answer 9

Tophi

Question 10

Derived from light chains ?

Answer 10

Amyloid light chain (AL) protein

Question 11

Derived from serum amyloid-associated (SAA ) protein ?

Answer 11

AA (Amyloid-associated protein)

Question 12

found in the cerebral lesions of Alzheimer disease ?

Answer 12

β-Amyloid (Aβ) protein

Question 13

Gross Staining of Amyloid ?

Answer 13

1- Lugol’s iodine

2- Iodine and 1% sulphuric acid

Question 14

Lugol’s iodine stains amyloid ?

Answer 14

dark brown & the rest of tissue pale yellow

Question 15

Iodine and 1% sulphuric acid: → stain the amyloid ?

Answer 15

blue

Question 16

in the Congo red stain the under ordinary light: → Amyloid deposits is stained ?

Answer 16

orange red

Question 17

In the Congo red stain the Under polarized light: → amyloid gives ?

Answer 17

apple-green birefringence

red-green

Question 18

Bence Jones protein ?

Answer 18

AL

Question 19

May cause carpal tunnel syndrome and joint disease ?

Answer 19

Aβ2M (β2-microglobulin protein)

Question 20

Familial Mediterranean fever ?

Answer 20

AA (Amyloid-associated protein)

Question 21

What is the type of Primary Amyloidosis ?

Answer 21

AL

Question 22

What is the type of Secondary Amyloidosis (Reactive Systemic Amyloidosis) ?

Answer 22

AA

Question 23

What is the type of Hemodialysis-associated amyloidosis and what is cause ?

Answer 23

Aβ2M (β2-microglobulin protein)

Cause carpal tunnel syndrome and joint disease

Question 24

What is the type of Familial (Hereditary) Amyloidosis ?

Answer 24

AA (Amyloid-associated protein)

Question 25

What is the type of Familial Mediterranean fever?

Answer 25

AA (Amyloid-associated protein)

Question 26

What is the type of Familial amyloidotic polyneuropathies ?

Answer 26

Mutant Transthyretin (TTR)

Question 27

What is the type of Amyloid of Aging ?

Answer 27

Transthyretin (TTR)

Question 28

What is the type of Systemic Senile Cardiac Amyloidosis: (Amyloid of Aging ) ?

Answer 28

Transthyretin (TTR)

Question 29

What is the type of Senile cerebral amyloidosis (Alzheimer disease) ?

Answer 29

Aβ (β-Amyloid protein)