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Path ( + A ) > 2- Neoplasia > Flashcards

2- Neoplasia Flashcards

1
Q

Example of Lymphatics Permeation ?

A

Breast carcinoma

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2
Q

What is the steps of Invasion of Extracellular Matrix (ECM) ?

A

1- Detachment
2- Attachment
3- Degradation
4- Migration

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3
Q

Metastasis is most common in ?

A

lymphatic & hematogenous (blood) spread.

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4
Q

LYMPHATIC SPREAD It occurs more commonly with ?

A

Carcinomas

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5
Q

Emboli drained by systemic veins are carried to ?

A

Right side of the heart

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6
Q

Emboli drained by the Portal vein are carried to ?

A

liver causing liver metastases

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7
Q

Spread occurs early by blood and rarely (10%) by lymphatics.

A

Sarcoma

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8
Q

Spread occurs early by lymphatics then later by blood,

A

Carcinomas

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9
Q

LYMPHATIC SPREAD It occurs more commonly with ?

A

Carcinomas

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10
Q

What is the carcinomas spread relatively early by blood ?

A

carcinoma of thyroid, liver, kidney, prostate & placenta

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11
Q

What is the The most common sites affected by metastases include ?

A

the liver, lungs, bones and brain.

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12
Q

In the Transperitoneal spread the carcinoma of stomach, colon is ?

A

metastatic Peritoneal nodules

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13
Q

In Transperitoneal spread In females, carcinoma of stomach, colon is ?

A

bilateral ovarian metastases (Krukenberg tumor)

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14
Q

In females, carcinoma of stomach, colon leads to ?

A

bilateral ovarian metastases (Krukenberg tumor)

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15
Q

Carcinoma in situ (CIS) represents a preinvasive stage of cancer and is characterized by severe or high grade epithelial dysplasia affecting whole thickness of epithelium without invasion of the basement membrane ?

A

CARCINOMA IN SITU

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16
Q

What is the Fate of CARCINOMA IN SITU ?

A

Progression into invasive carcinoma

17
Q

Direct spread to a surface (skin or mucosa) leads to ulceration ?

A

malignant ulcer

18
Q

Direct spread from one hollow organ to another adjacent one causes a ?

A

malignant fistula

19
Q

Examples of locally malignant tumor ?

A

1- Basal cell carcinoma

2- Giant cell tumor of bone (osteoclastoma)

20
Q

Examples of locally malignant tumors ?

A

1- Basal cell carcinoma.

2- Giant cell tumor of bone (osteoclastoma).

21
Q

The most common sites affected by metastases include:

A

liver, lungs, bones and brain.

22
Q

What is the gross of Metastases ?

A

appear as scattered multiple round nodules

23
Q

Give example of Lymphatic Permeation ?

A

Breast carcinoma

24
Q

tumors of organs drained by the Portal vein are carried to ?

A

liver causing liver metastases

Path ( + A ) (23 decks)

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