Inf. diseases II - Swine diseases (resp.+joints) Flashcards
PNEUMONIC PASTEURELLOSIS causative agent:
gram neg. facultatively anaerobic,
non-moving, non-hemolytic
Pasteurella multocida
Pasteurella multocida is commonly isolated from the lungs of pigs with: (3)
Chronic pneumonia
Purulent bronchopneumonia
Pleuritis
P. multocida is a common secondary infection in the lungs of pigs with (2)
enzootic pneumonia associated with M. hyopneumoniae.
Also common in association with Actinobacillus pleuropneumoniae.
PNEUMONIC PASTEURELLOSIS is a sporadic disease of swine, caused by Pasteurella multocida, and characterized by
acute bronchopneumonia.
Most common serotype of Pasteurella multocida (in what %?)
Capsular serotype A (88%)
How many serotypes of P. multocida?
Which are most common?
16 serotypes – most common: 3 and 5
(capsular serotype A makes up 88% of cases)
What enzymes is P.multocida positive and negative for?
Oxidase and indole positive,
urease negative
Survival of P.multocida in the environment
Can survive in water for 14 days
In aerosols in low humidity: 1h
Host range of pneumonic pasteurellosis
pigs
Although found in other species it is generally assumed that there is little interspecies transfer.
Where does P.multocida typically reside?
carried in the nasal cavity and tonsils of clinically healthy pigs
In ill pigs, isolated in the lungs.
Mortality of pneumonic pasteurellosis?
Mortality 5-40%
Transmission of pneumonic pasteurellosis
Excretion: respiratory
Direct contact
Aerosols
Route: inhalation or ingestion
Sporadic cases of acute bronchopneumonia (pneumonic pasteurellosis) is seen in what age group?
in grower-finisher pigs
Clinical signs of pneumonic pasteurellosis
Fever <41°C
Anorexia, lethargy
Respiratory distress with labored respiration and increased lung sounds leads to
breathing through the mouth.
Cyanosis
Death in 4-7 days if not treated
pneumonic pasteurellosis May also exist in chronic form within pigs in a herd as part of
the swine pneumonia complex
Post mortem signs of pneumonic pasteurellosis (3)
Chronic bronchopneumonia with abscessation
Pleuritis, pericarditis
Material for diagnosis of pneumonic pasteurellosis (3)
BAL
Swab from nasal cavity
Lung tissue
Lab analyses for diagnosis of pneumonic pasteurellosis (1)
Isolate the agent
TX for pneumonic pasteurellosis (1)
Abs
Can be effective if started early
Prevention & control pneumonic pasteurellosis
Vaccination ineffective: None available in Estonia
Preventative measures are the same as for enzootic pneumonia
All-in-all-out systems are preferred
Swine flu, also known as?
Is caused by? (3)
Swine influenza
Swine Influenza A virus subtypes H1N1, H1N2 and H3N2
SWINE INFLUENZA is a very contagious disease of swine, caused by Orthomyxovirus, and characterized by
fever, muscle stiffness and thumps.
Swine influenza genus and family
G.Alpha influenza virus
F.Orthomyxoviridae
Subtypes of swine influenza virus (3)
H1N1, H1N2,
H3N2
Pig H1N1 and human H1N1 have a common
avian ancestor
Host range of swine influenza virus: (2)
pigs (mostly piglets), humans
Last pandemic in humans: 2010
Avian H1N1 can be pathogenic to pigs
Season for swine influenza virus cases?
fall-winter
Morbidity of swine influenza virus?
Morbidity 100%
Mortality of swine influenza virus?
Mortality (case fatality) <5%
Transmission of swine influenza virus
Excretion: saliva, nasal and ocular discharge
Aerogenic (droplets)
Route: respiratory
After recovery pigs may become carriers.
IP of swine influenza virus:
1-3 days (2-7 days)
Clinical signs of swine influenza virus (5+)
Depression, weakness, anorexia
Fever 42°C
Dyspnea, coughing, ‘thumps’
Mucous discharge from nose and eyes
Prostration
Can become chronic
Recovery in 4-6 days
Post mortem signs of swine influenza virus (3)
LNs – swelling and edema
Pneumonic areas of lungs – demarcated, collapsed, purplish red. More severe ventrally.
Mucopurulent exudate from airways
Material for diagnosis of swine influenza virus (3)
Swabs from nasal cavity
Blood
Lungs
Lab analyses for diagnosis of swine influenza virus (3)
Serology (ELISA) – antibodies, to estimate hemagglutination titer.
PCR – to detect virus
Histology
Tx for swine influenza virus
no specific Tx
If secondary infections: ABs.
To minimize secondary bacterial pneumonia: ABs in drinking water/feed profylactically in some countries.
Prevention & control of swine influenza virus.
Good housing – prevent severe outbreaks.
Vaccines – no documented evidence to support their use. In Estonia: Gripovac 3 and RESPIPORC FLU 3
Recovered animals become immune to subsequent infection for <3 months.