Immunology Flashcards
What are some of the physiological functions mucosal tissue?
- gas exchange
- food absorption
- sensory activities
Why is the gut naturally immune suppressed?
- you don’t want to over-react to non-harmful substances
What is Peyer’s patch?
-group of lymphoid tissues found in the ileum of the small intestine
What are Peyer’s patches covered in?
- epithelial cells and contain specialised cells called M cells
What are M cells?
- found on Peyer’s patches
- have characteristic membrane ruffles - microvilli
- increase surface area –> good at absorption
What is found in the germinal centre of the Peyer’s patch?
- T cells
How can dendritic cells sample antigens from the lumen of the gut?
- they can extend processes across the epithelial layer
- don’t only need to be in peyer’s patches
Where does the immune response occur in mucosa immunity
- lamina propria
- layer of loose connective tissue
- present with many different immune cells
What are standard homing receptors in the gut?
- CCR7
- CCR9
- CCR10
- L - selectin
- Think of it as post codes, directs lymphocytes to a specific location
Name of the lymph nodes associated with the gut?
- mesenteric lymph nodes
What is the most common immunoglobin in the gut?
- IgA
- DIMERIC!
Why does the IgA have secretory components?
- as a protection, to prevent it being broken down
Why might a baby experience immunodeficiency from 6 months?
- maternal immunoglobulins gone
Atypical inflammatory bowel disease in a child?
-CGD –> Chronic Granulomatous Disease
How is a food allergy initiated?
- type I hypersensitivity
- imitated by cross linking of allergen, specific IgE on the surface of mast cell with the specific allergen
- memory response
