Drug treatments Flashcards
Name a PPI
- Omeprazole
- lansoprazole
How do PPI work?
- inhibition of gastric gland parietal cell H+/K+ ATPase
What are PPIs used for?
- treatment of peptic ulcers
- Dyspepsia and GORD
- H.pylori infections
Name a histamine (H2) Receptor antagonist
- ranitidine
How do H2 receptor antagonists work?
- competitive antagonist of H2 receptor on basolateral of parietal cell
What are H2 receptor antagonists used for?
- prevention and treatment of peptic ulcers
- dyspepsia and GORD
Name a alginate and anatacid
- gaviscon
- peptac
How do anatcids work
- act as buffers rasing the pH of gastric juices
What are antacids used for?
- treatment of dyspepsia and GORD
Name an antimuscarinic
- hyoscine butylbromide
How do antimuscarinics work
- oppose a parasympathic stimulation
What are antimuscarinics used for
- treatment of the smooth muscle spasms associated with IBS
Name an antimotility drug
- loperamide
How do antimotility drugs work
- increase tone and rhythmic contractions
What are antimotility drugs used for?
- diarrhoea symptoms
Name a aminosalicylates drug
- mesalazine
How do Aminosalicylates work?
- anti-inflammaotry
- immunesuppression effect
What are aminosalicylates used for?
- treatment of ulcerative colitis
- rheumatoid arthitis
Name a bulk forming laxative?
- ispagula husk
Name an osmotic laxative
- lactulose
How do laxatives work?
- pull water into the lumen to reduce constipation
Name a antiemetic dopamine D2 receptor antagonist
- domperidone
What are antiemetic dopamine D2 receptor antagonists used for?
- treatment of nausea and vomiting
- treatment of GORD
Name an antiemetic Histamine H1 receptor antagonist
- cyclizine
Name an antiemetic 5-HT3 receptor antagonist
- Ondansetron
