Crohns and Ulcerative Colitis Flashcards
What does IBD stand for?
- irritable bowel disease
Define Crohn’s disease?
- chronic inflammatory and ulcerating condition of the GI tract that can affect anywhere from the mouth to the anus
Where are the most common sites for Crohn’s disease?
- terminal ileum and colon
- transmural inflammation
Define Ulcerative Colitis
- chronic inflammatory disorder confined to the colon and the rectum
Where is Ulcerative Colitis most likely to affect?
- colon and rectum
- mucosal and submucosal infammation
What are the symptoms of Crohn’s disease?
- abdominal pain
- diarrohea
- bleeding PR
- aneamia
- weight loss
Explain the pathology of Crohn’s disease
- granuloma formation
- increased chronic inflammatory cells in the lamina propria
- deep fissures
- skin lesions
Cobblestonning of the mucosa is a red flag for what disease?
- Crohn’s
What are the complications that can arise from Crohn’s disease?
- malabsorption
- short bowel syndrome
- fistulas
Describe the immune response in Crohn’s disease
- persistent activation of T-cells and macrophages
What are the symptoms of Ulcerative Colitis?
- diarrhoea
- mucus in poo
- blood PR
Explain the pathology of Ulcerative Colitis
- diffuse continuous disease almost always involving the rectum
- irregular shaped branching crypts
- no granulomas
- superficial only!
What are the treatments of Ulcerative Colitis?
- steroids
- subtotal colectomy (if persistent)
What may be some complications that arise from Ulcerative Colitis?
- toxic megacolon
- anal fissures
- high cancer risk
Explain the immune response in Ulcerative Colitis
- persistent activation of T-cells and macrophages
- excess proinflammatory cytokines produced
