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Theriogenology > Hormonal Therapy > Flashcards

Hormonal Therapy Flashcards

1
Q

what are prostaglandins?

A

20-carbon atom derivatives of fatty acids arachadonic acid and di-homo-gamma-linolenic acid

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2
Q

what does PGF2alpha do?

A

luteolytic
causes regression of corpus luteum

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3
Q

where is GnRH released?

A

hypothalamic surge and tonic centers

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4
Q

where is oxytocin stored?

A

posterior lobe of pituitary

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5
Q

what are the two components of luteinizing hormone and follicle stimulating hormone?

A

alpha subunit: identical
beta subunit: changes in each

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6
Q

what is alizin/aglepristone?

A

progesterone antagonist

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7
Q

when should you monitor estrus after giving a prostaglandin injection to a cow?

A

2-6 days after

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8
Q

is prostaglandin an effective drug for short-cycling sows?

A

no: CL not responsive until days 12-14 and naturally lyses at day 15

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9
Q

what would you use to suppress estrus in a mare?

A

altrenogest/regumate (brand for horses)
alternative brand for sows, same drug

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10
Q

how would you stimulate onset of first estrus in prepubertal gilts?

A

PG600
boar exposure
travel
combination

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11
Q

what can you use to synchronize estrus in weaned sows?

A

check for heat 4-6 days post weaning
triptorelin
based on weaning time

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12
Q

what can you use to sychronize estrus in pubertal and cyclic gilts?

A

progesterone
PG600
GnRH
triptorelin

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13
Q

is a single dose of prostaglandin effective at inducing abortion in a mare after day 40?

A

no
endometrial cups have been formed

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14
Q

what are thee biochemical classifications of hormone therapy?

A

peptides
glycoproteins
steroids
prostaglandins

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15
Q

which drugs are neuropeptides?

A

GnRH
oxytocin

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16
Q

what are the glycoproteins?

A

FSH
LH
eCG/PMSG
hCG
AMH

17
Q

what do prostaglandins play a critical role in?

A

ovulation
passage of early embryo through oviduct
intrauterine migration of conceptus during maternal recognition of pregnancy- mare
cervical relaxation and uterine contraction during parturition

18
Q

which prostaglandins are important in reproduction?

A

PGF
PGE
PGF2alpha luteolytic: regression CL

19
Q

what are steroid hormones derived from?

A

cholesterol

20
Q

where are steroid hormones produced?

A

adrenal cortex and gonads

21
Q

which steroid hormones are responsible for sexual promotion?

A

estrogen
progesterone
testosterone

22
Q

what is regu-mate/altrenogest?

A

synthetic progestin

23
Q

what is melengestrol acetate used for?

A

growth promoting feed additive cattle
estrus suppression heifers for slaughter or breeding management

24
Q

what are some problems with megestrol acetate?

A

irritating when injected
may induce endometrial hyperplasia/pyometra in bitch/queen
decreases resistance to bacteria and closes cervix: may lead to metritis
exacerbates mammary tumors in bitch
mastitis

25
Q

what is GnRH released by?

A

hypothalamic surge and tonic centers

26
Q

where is oxytocin synthesized?

A

posterior lobe of pituitary

27
Q

what is the main side effect of GnRH/deslorelin?

A

injection site swelling

28
Q

what is triptorelin acetate/GnRH used for?

A

intravaginal use for weaned sows for single fixed time AI

29
Q

what do you need to have uterine effects of oxytocin?

A

estrogen priming prior to oxytocin
not in mares

30
Q

are FSH and LH antigenic?

A

yes

31
Q

what are LH and FSH available as?

A

pituitary, serum, urine extracts

32
Q

what is human chorionic gonadotropin/

A

LH analog used for LH activity
glycoprotein hormone

33
Q

what is a brand name of human chorionic gonadotropin?

A

PG600

34
Q

what is porcine pituitary-derived follicle stimulating hormone?

A

glycoprotein hormone
only FSH product approved by FDA
from swine pituitary, usually has LH contamination

35
Q

what does a progesterone antagonist do?

A

competitive antagonism of progesterone and blocking the hormone responsible for implantation and pregnancy maintenance

36
Q

how can you terminate a pregnancy in a sheep?

A

cloprostenol or dinoprost before 55 days (CL maintains until 50-60 days)
dexamethasone after 55 days

37
Q

what can you give a cow to induce parturition?

A

dexamethasone
flumethasone

Theriogenology (15 decks)

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