Hepatitis viruses Flashcards
1
Q
signs and symptoms of all hepatitis viruses:
A
- episodes of fever
- jaundice
- inc ALT
- inc ASt
2
Q
naked hepatitis viruses
A
- includes HAV and HEV
- lack an envelope
- not destroyed by the gut
- “the vowels hit your bowels”
3
Q
HBV DNA polymerase
A
- has DNA and RNA dependent activities
- upon entry into nucleus, the polymerase completes the partial dsDNA
- host RNA polymerase transcribes mRNA from viral DNA to make viral proteins
- the DNA polymerase then reverse transcribes viral RNA to DNA, which is the genome of the progeny virus
4
Q
HCV hepatitis virus
A
- lacks 3’-5’ exonuclease activity –> variation in antigenic structures of HCV envelope proteins
- host antibody production lags behind production of new mutant strains of HCV
5
Q
HAV–virus family
A
- RNA picronavirus
6
Q
HAV–transmission
A
- fecal-oral
- shellfish
- travelers
- day care
7
Q
HAV–incubation
A
- short (weeks)
8
Q
HAV–clinical course
A
- Asymptomatic (usually)
- Acute
9
Q
HAV–prognosis
A
- good
10
Q
HAV–HCC risk
A
- No
11
Q
HAV–liver biopsy
A
- hepatocyte swelling
- monocyte infiltration
- councilman bodies
12
Q
HAV–carrier state
A
- no carrier state (“Alone”)
13
Q
HBV–family
A
- DNA hepadnavirus
14
Q
HBV–transmission
A
- parenteral (Blood)
- sexual (Baby making)
- perinatal (Birthing)
15
Q
HBV–incubation
A
- long (months)
16
Q
HBV–clinical course
A
- initially like serum sickness
- fever
- arthralgias
- rash
- may progress to carcinoma
17
Q
HBV–prognosis
A
- most adults have full resolution
- minority have chronic infection
18
Q
HBV–HCC risk
A
- Yes
19
Q
HBV–liver biopsy
A
- granular eosinophilic “ground glass” appearance
- cytotoxic T cells mediate damage
20
Q
HBV–carrier state
A
- carrier state is common
21
Q
HCV–family
A
- RNA flavivirus
22
Q
HCV–transmission
A
- primarily blood
- IVDU, post transfusion
23
Q
HCV–incubation
A
- long
