DNA Viruses

Question 1

what are the 5 general rules for all DNA viruses?

Answer 1

• are HHAPPPPy viruses
• are double stranded
  
  • except parvo (single stranded)
• have linear genomes
  
  • except papilloma and polyoma (circular, supercoiled) and hepadna (circular, incomplete)
• are icosahedral
  
  • except pox (complex)
• replicate in the nucleus
  
  • except pox (carroes own DNA dependent RNA polymerase)

Question 2

what are the HHAPPPPY viruses?

Answer 2

• DNA viruses:
  
  • Hepadna
  • Herpes
  • Adeno
  • Pox
  • Parvo
  • Papilloma
  • Polyoma

Question 3

Herpesviruses–envelope?

Answer 3

• YES

Question 4

Herpesviruses–DNA structure

Answer 4

• DS and linear

Question 5

Poxvirus–envelope?

Answer 5

• YES

Question 6

Poxvirus–DNA structure

Answer 6

• DS and linear (largest DNA virus)

Question 7

Poxvirus–medical importance

Answer 7

• Smallpow–eradicated world wide by use of live attenuated vaccine
• Cowpox–“milkmaid blisters”
• Molluscum contagiosum–flesh colored papule with central umbilication

Question 8

Hepadnavirus–envelope?

Answer 8

• YES

Question 9

Hepadnavirus–DNA structure

Answer 9

• partially DS and circular

Question 10

Hepadnavirus–medical importance

Answer 10

• HBV
  
  • acute or chronic hepatitis
  • not a retrovirus but has reverse transcriptase

Question 11

Adenovirus–envelope?

Answer 11

• NO

Question 12

Adenovirus–DNA structure

Answer 12

• DS and linear

Question 13

Adenovirus–medical importance

Answer 13

• febrile pharyngitis (A)–sore throat
• acute hemorrhagic cystitis
• pneumonia
• conjunctivitis–“pink eye”

Question 14

Papillomavirus–envelope?

Answer 14

• NO

Question 15

Papillomavirus–DNA structure

Answer 15

• DS and circular

Question 16

Papillomavirus–medical importance

Answer 16

• HPV–warts
  
  • serotypes 1, 2, 6, 11
• CIN
• cervical cancer
  
  • most commonly 16, 18

Question 17

Polyomavirus–envelope?

Answer 17

• NO

Question 18

Polyomavirus–DNA structure

Answer 18

• DS and circulat

Question 19

Polyomavirus–medical importance

Answer 19

• JC virus–progressive multifocal leukoencephalopathy (PML) in HIV
• BK virus–transplant patients, commonly targets kidney
  
  • “JC: Junky Cerebrum; BK: Bad Kidney

Question 20

Parvovirus–envelope?

Answer 20

• NO

Question 21

Parvovirus–DNA structure

Answer 21

• SS and linear
  
  • smallest DNA virus

Question 22

Parvovirus–medical importance

Answer 22

• B19 virus–aplastic crises in sickle cell disease, “slapped cheeks” rash in children (erythema infectiosum or fifth disease)
• RBC destruction in fetus leads to hydrops fetalis and death
  
  • in adults, leads to pure RBC aplasia and rheumatoid arthritis-like symptoms