DNA Viruses Flashcards
1
Q
what are the 5 general rules for all DNA viruses?
A
- are HHAPPPPy viruses
- are double stranded
- except parvo (single stranded)
- have linear genomes
- except papilloma and polyoma (circular, supercoiled) and hepadna (circular, incomplete)
- are icosahedral
- except pox (complex)
- replicate in the nucleus
- except pox (carroes own DNA dependent RNA polymerase)
2
Q
what are the HHAPPPPY viruses?
A
- DNA viruses:
- Hepadna
- Herpes
- Adeno
- Pox
- Parvo
- Papilloma
- Polyoma
3
Q
Herpesviruses–envelope?
A
- YES
4
Q
Herpesviruses–DNA structure
A
- DS and linear
5
Q
Poxvirus–envelope?
A
- YES
6
Q
Poxvirus–DNA structure
A
- DS and linear (largest DNA virus)
7
Q
Poxvirus–medical importance
A
- Smallpow–eradicated world wide by use of live attenuated vaccine
- Cowpox–“milkmaid blisters”
- Molluscum contagiosum–flesh colored papule with central umbilication
8
Q
Hepadnavirus–envelope?
A
- YES
9
Q
Hepadnavirus–DNA structure
A
- partially DS and circular
10
Q
Hepadnavirus–medical importance
A
- HBV
- acute or chronic hepatitis
- not a retrovirus but has reverse transcriptase
11
Q
Adenovirus–envelope?
A
- NO
12
Q
Adenovirus–DNA structure
A
- DS and linear
13
Q
Adenovirus–medical importance
A
- febrile pharyngitis (A)–sore throat
- acute hemorrhagic cystitis
- pneumonia
- conjunctivitis–“pink eye”

14
Q
Papillomavirus–envelope?
A
- NO
15
Q
Papillomavirus–DNA structure
A
- DS and circular
16
Q
Papillomavirus–medical importance
A
- HPV–warts
- serotypes 1, 2, 6, 11
- CIN
- cervical cancer
- most commonly 16, 18
17
Q
Polyomavirus–envelope?
A
- NO
18
Q
Polyomavirus–DNA structure
A
- DS and circulat
19
Q
Polyomavirus–medical importance
A
- JC virus–progressive multifocal leukoencephalopathy (PML) in HIV
- BK virus–transplant patients, commonly targets kidney
- “JC: Junky Cerebrum; BK: Bad Kidney
20
Q
Parvovirus–envelope?
A
- NO
21
Q
Parvovirus–DNA structure
A
- SS and linear
- smallest DNA virus
22
Q
Parvovirus–medical importance
A
- B19 virus–aplastic crises in sickle cell disease, “slapped cheeks” rash in children (erythema infectiosum or fifth disease)
- RBC destruction in fetus leads to hydrops fetalis and death
- in adults, leads to pure RBC aplasia and rheumatoid arthritis-like symptoms