Heme2c Flashcards
1
Q
What are the myeloproliferative neoplasms?
A
a. Polycythemia Vera
b. CML
c. Essential Thrombocytosis
d. Primary Myelofibrosis
2
Q
What does JAK2 do?
A
It turns off the production signaling. So if it doesn’t work, like in many neoplasms, things keep getting produced.
3
Q
What are the major abnormalities for PV, ET and PM?
A
PV: JAK2 = 87%
ET: JAK2 = 60%, CALR = 25%
PM: JAK2 = 50%, CALR = 35%
4
Q
What drugs do you use to harvest HSC from the blood?
A
GCSF to make more HSC.
Plerixafor to release the HSCs into the blood stream (it cuts CXCR4 and SDF-1)
