Heme2a

Question 1

What is the translocation for Burkitt lymphoma?

Answer 1

t(8;14) c-myc

Question 2

What is the translocation for Follicular Lymphoma?

Answer 2

t(14;18) bcl-2

Question 3

What is the translocation for AML M3 type?

Answer 3

t(15;17) APL:RARA

Question 4

What is the translocation for Ewing sarcoma?

Answer 4

t(11;22)

Question 5

What is the translocation for Mantle Cell Lymphoma?

Answer 5

t(11;14)

Question 6

What is the translocation for CML?

Answer 6

t(9:22) Ph chromosome

Question 7

What are the 3 major conditions associated with multiple myeloma?

Answer 7

a. Plasma cells activate RANK receptors on osteoclasts will break down bone.
b. Monoclonal Ig is made- M spike but low diversity
c. Lights chains are also released- proteinuria and high serum protein

Question 8

What is MGUS?

Answer 8

High serum protein (M spike), but not other symptoms of MM.

Question 9

What is the difference in Ig_ between MM and Waldenstrom?

Answer 9

MM: IgG and sometimes IgA

Waldenstrom: IgM

Question 10

On what test is the M spike detected?

Answer 10

SPEP

Question 11

What are the three under the umbrella of myeloproliferative disorder?

Answer 11

a. Polycythemia vera
b. CML
c. Essential Thrombocythemia

Question 12

What two conditions can have hyperviscosity?

Answer 12

a. Polycythemia Vera (low EPO is a hallmark)

b. Waldenstroms: high IgM

Question 13

What three conditions have a JAK2 mutation?

Answer 13

a. Polycythemia Vera
b. Myelofibrosis
c. Essential Thrombocythemia

Question 14

CML

a. What cells are especially elevated?
b. What is the mutation?
c. What receptor is involved?
d. How do you treat it?
e. How can you distinguish CML from infection?

Answer 14

a. basophils
b. (9;22) BCR;ABL
c. tyrosine kinase
d. imatinib
e. granulocytes are LAP(-)

Question 15

Can CML become AML or ALL?

Answer 15

Both. 2/3 become AML. 1/3 become ALL.

The mutation is in the CD34+ HSC.

Question 16

How do you treat Follicular Lymphoma?

Answer 16

Rituximab (anti CD20)

Question 17

What virus can cause Marginal Zone Lymphoma?

Answer 17

H. pylori

Question 18

Reed-Sternberg cells are CD_?

Answer 18

CD 15+ and CD30+

Question 19

What are the 4 types of Hodgkins Lymphoma?

Answer 19

a. Nodular Sclerosing (70%)
b. Lymphocyte Rich (best prognosis)
c. Lymphocyte Depleted (worst prognosis)
d. Mixed Cellularity (lots of eosinophils)

Question 20

What is the normal range for WBCs?

Answer 20

5K to 10K

Question 21

Hodgkins is associated with an increase in IL-_?

Answer 21

IL-5

Question 22

What is the definition of acute leukemia?

Answer 22

> 20% blasts in marrow

Question 23

What diseases are tDt+?

Answer 23

ALL

Question 24

What are two characteristics of Acute Monocytic Leukemia?

Answer 24

a. Goes to the gums

b. no MPO

Question 25

What requires prophylaxis for your brain and balls?

Answer 25

B-ALL

Question 26

What disease has smudge cells? What is a major symptom? And these B cells are CD? and CD?

Answer 26

CLL
Hypogammaglobulinemia
CD5+ and CD20+

Question 27

Adult T Cell Leukemia Lymphoma has CD_ T cells, and what symptom distinguishes it from MM?

Answer 27

CD4+ T Cells.

Rash distinguishes it from MM.

Question 28

What are the 3 requirements for MM?

Answer 28

a. monoclonal plasma cells in marrow >= 10%
b. monoclonal protein present in serum or urine
c. CRAB (myeloma related organ dysfunction)

Question 29

What is the most common chromosome abnormality in MM?

Answer 29

14q32

Question 30

Low albumin levels in MM are associated with what?

Answer 30

IL-6