Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Cell Biology > Hematopoiesis > Flashcards

Hematopoiesis Flashcards

You may prefer our related Brainscape-certified flashcards:
AP® Biology flashcards Biology 101 flashcards
1
Q

What is myeloid tissue?

A

Tissue that actively produces erythrocytes, platelets, and leukocytes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What is present in the myeloid tissue?

A

Developing blood cells suspended in a loose connective tissue stroma and large sinusoids with macrophages

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Are stem cells present in myeloid tissue?

A

Yes, blood cells are a continuously renewing cell population

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

How is myeloid tissue distributed in the fetus?

In the adult?

A

Fetus: All bone marrow is actively hemopoietic, and hemopoiesis also occurs in liver, kidney and spleen

Adutl: Some bone marrow is hemopoietic (pelvis, sternum, ribs, vertebrae, cranial bones, femur, humerus) and during times of severe need for blood cells, fatty marrow is converted to hemopoietic marrow and extramedullary hemopoiesis occurs (liver, spleen, kidney)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What are the hemopoietic cell populations?

A

Stem cells, progenitor cells, maturing cells, stromal cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What are stem cells

A

totipotent or pluripotent and capable of self renewal

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What are progenitor cells

A

Committed cells for a specific lineage. Colony forming units

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What are maturing cells

A

Cells that result from differentiation from progenitor cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What are pluripotent stem cells?

A

Develop in the mesenchyme associated with the fetal yolk sac (liver first, spleen and bone marrow, then kidney)

Circulate in very small numbers in adult peripheral blood and resemble lymphocytes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Describe the maturation of blood cells

A

As differentiation progresses cells become smaller, nucleus becomes smaller and heterochromatic

RBC cytoplasm changes from basohilic to pale eosinophilic

For granulocytes, specific granules appear in the cytoplasm

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Tell tale signs a cell is not a RBC

A

any degree of non-round nucleus

Granules in cytoplasm

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What is a rubriblast

A

1st stage erythrocyte

Large, deeply basophilic, no cytoplasm

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What is a prorubricyte

A

More cytoplasm and less vesicular than rubriblast

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What is a rubricyte

A

Mottled nucleus and cytoplasm (both basophilic and acidophilic)

Heterochomratic nucleus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What is a metarubricyte?

A

Close in size to RBC, nucleus is dense and round

Cytoplasm is basophilic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What is a reticulocyte

A

No nucleus
Close in size to RBC, slightly bigger
Cytoplasm is gray-ish, slightly more basophilic than RBC, clumps of ribosomes may be visible

Circulates in very smal number (only precursor that is normal in peripheral blood)

17
Q

Causes of anemia

A

Reduction in RBC number, hemoglobin content or both

Most common hematologic disorder

Symptom, not disease due to blood loss, hemolysis, decreased RBC production

18
Q

What is regenerative anemia?

A

Marrow responds by releasing immature RBCs

Reticulocyte count goes up (best indicator of regeneration)

Mean corpuscular volume goes up and mean corpuscular hemoglobin concentration goes down (because reticulocytes have less hemoglobin)

19
Q

What is granulocytopoiesis

A

Stages of granulocyte development

Cels become smaller as they mature, the nucleus is round early and becomes indented or multi-nucleated

Abundant cytoplasm granules

20
Q

Myeloblast characteristics

A

Larger than rubriblast

More cytoplasm

21
Q

Characteristics of promyelocyte

A

Non-specific granules first appear

22
Q

Characteristics of myelocyte

A

Nucleus is round or oval, specific granules appear (eosinophilic granules, basophilic granules, neutrophil granules respectively)

23
Q

Characteristics of metamyelocyte

A

Nucleus becomes bean shaped (indented less than 1/2 diameter of nucleus)

24
Q

Characteristics of band cell

A

Horseshoe nucleus

The indentation goes more than halfway across the nucleus

25
Q

Which blood cell has the most lobulated nucleus

A

Neutrophil

26
Q

Which granulocytes share the same color granules with a Wright’s stain?

A

Basophils and mast cells

27
Q

What does the total neutrophil count reflect?

A

the balance between marrow production, release in to circulation, and tissue demand

28
Q

What is a left shift in neutrophil dynamics?

A

Regenerative if associated with neutrophilia

degenerative without neutrophilia (or with neutrophenia [toxic]) or if there are more nonsegmented cells than mature cells

29
Q

What are thrombocytopoiesis stages

A

Megakaryoblast: Very large ovoid nucleus with nucleoli

Promegakaryocyte (don’t worry): Divided nuclei

Megakaryocyte: Large cell with multilobed, heterochromatic nucleus

Basophilic or acidophilic cytoplasm

Platelets detach at periphery

30
Q

Where are megakaryocytes usually found?

A

Near a sinusoid with other hemopoietic tissue

Cell Biology (20 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions