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Hematología Flashcards

1
Q

Most frequent cause of transient aplastic crisis in patients with chronic hemolytic anemia

ACP April 2008

A

Parvovirus B19 infection

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2
Q

Major use of cryoprecipitate is to replace this blood component

ACP April 2008

A

Fibrinogen

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3
Q

Most common enzyme deficiency associated with these red blood cells

ACP April 2008

A

Glucose 6-phosphate deficiency

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4
Q

Important cause of recurrent abdominal pain in patients with paroxysmal nocturnal hemoglobinuria

ACP April 2008

A

Portal or mesenteric thrombosis

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5
Q

Disease associated with “sausaging” of retinal veins

ACP April 2008

A

Macroglobulinemia (accept Waldenstrom’s, hyperviscosity syndrome)

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6
Q

Term for eating of nonfood substances

ACP August 2024

A

Pica

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7
Q

Technical name for ‘bite cells’ on a peripheral blood smear

ACP August 2024

A

Degmacytes

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8
Q

Diagnosis for a patient with mild microcytic, hypochromic anemia, target cells, and normal hemoglobin electrophoresis

ACP August 2024

A

α-Thalassemia trait (α-thalassemia minor)

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9
Q

Most common type of acute porphyria worldwide

ACP August 2024

A

Acute intermittent porphyria

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10
Q

Characteristic peripheral smear finding in addition to thrombocytopenia in Bernard-Soulier syndrome and May-Hegglin anomaly

ACP August 2024

A

Giant platelets (accept macrothrombocytes or abnormally large platelets

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11
Q

Nuclear remnant in red blood cells of asplenic patients

ACP July 2024

A

Howell-Jolly body

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12
Q

Factor deficiencies in hemophilia A, B and C

ACP July 2024

A

VIII, IX, XI (must list all three)

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13
Q

Two most common organ systems affected by leukostasis syndrome

ACP July 2024

A

Central nervous system (CNS) and pulmonary

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14
Q

Antibiotic used as an in-vitro assay for von Willebrand factor binding to platelet receptor glycoprotein Ib

ACP July 2024

A

Ristocetin

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15
Q

Lipid abnormality used as diagnostic criteria for hemophagocytic lymphohistiocytosis

ACP July 2024

A

Hypertriglyceridemia

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16
Q

Name of thalassemia condition characterized by two normal alpha globin chain genes

ACP may 2019

A

Alpha thalassemia trait (accept alpha thalassemia minor)

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17
Q

Test to diagnose acute intermittent porphyria

ACP may 2019

A

Urinary porphobilinogen (accept urine porphyrin)

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18
Q

Two FDA approved direct factor Xa inhibitor oral anticoagulants for VTE monotherapy

ACP may 2019

A

Rivaroxaban and apixaban

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19
Q

Syndrome consisting of eosinophilia without a secondary cause and organ dysfunction

ACP may 2019

A

Hypereosinophilic syndrome

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20
Q

Initial diagnostic study for all patients with confirmed amyloidosis

ACP may 2019

A

Amyloid typing

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21
Q

Diagnosis for Hgb 5.5 gm/dL with 0.1% reticulocytes and normal platelet count, leukocyte count, and bilirubin

ACP september 2019

A

Pure red cell aplasia

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22
Q

Underlying diagnosis responsible for this peripheral blood smear following treatment with nitrofurantoin

Falta imagen

ACP september 2019

A

G6PD deficiency

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23
Q

Diagnosis for splanchnic thrombosis, pancytopenia, and non-immune hemolytic anemia

ACP september 2019

A

Paroxysmal nocturnal hemoglobinuria

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24
Q

Most common scoring system used to assess the probability of heparin-induced thrombocytopenia

ACP september 2019

A

4T’s score

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25
Agent that reverses dabigatran anticoagulant effect ## Footnote ACP september 2019
Idarucizumab (accept Praxbind)
26
Diagnostic test for this hereditary condition | Falta imagen ## Footnote ACP January 2020
Osmotic fragility test
27
Mechanism of action of dabigatran ## Footnote ACP January 2020
Direct thrombin inhibitor
28
Diagnosis suggested by positive Coombs test for bound complement ## Footnote ACP January 2020
Cold agglutinin disease (cold hemolytic anemia)
29
Two most common organ system dysfunctions associated with leukostasis syndrome ## Footnote ACP January 2020
Pulmonary and CNS
30
Diagnosis associated with 25% hemoglobin A, 5% hemoglobin A2, and 65% hemoglobin ## Footnote ACP January 2020
Sickle cell β-thalassemia
31
Most patients with leukostasis syndrome are also at risk for this oncological emergency ## Footnote ACP November 2017
Tumor lysis syndrome
32
Playing this musical instrument is classically associated with intravascular hemolysis ## Footnote ACP November 2017
Bongo drum
33
Two diagnoses most commonly accounting for acute fall in hemoglobin in patients with sickle cell anemia ## Footnote ACP November 2017
Aplastic crisis and hyperhemolytic crisis
34
Definitive treatment for porphyria cutanea tarda ## Footnote ACP November 2017
Phlebotomy
35
Giant hemangiomas can be associated with this coagulation disorder syndrome ## Footnote ACP November 2017
DIC (also accept Kasabach-Merritt syndrome)
36
Coagulation study prolonged in hemophilia A and B ## Footnote ACP November 2021
Activated partial thromboplastin time (accept aPTT or PTT)
37
Pretransfusion erythrocyte treatment to reduce risk of transfusion-associated graft-versus-host disease ## Footnote ACP November 2021
Irradiation
38
Increased hepatic deposition of this inorganic substance plays a central role in the pathogenesis of porphyria cutanea tarda ## Footnote ACP November 2021
Iron
39
Therapy that decreases recurrent stroke in sickle cell disease ## Footnote ACP November 2021
Transfusion (accept exchange transfusion or hypertransfusion)
40
Systemic syndrome characterized by engulfment of blood cells by macrophages ## Footnote ACP November 2021
Hemophagocytic lymphohistiocytosis
41
Test to detect antibody and complement on the erythrocyte surface ## Footnote ACP September 2020
Direct antiglobulin (Coombs) test
42
Condition characterized by an elevated blast cell count and symptoms of decreased tissue perfusion ## Footnote ACP September 2020
Leukostasis syndrome (accept symptomatic hyperleukocytosis)
43
All direct oral anticoagulants with generic name ending in 'xaban' have this common mechanism of action ## Footnote ACP September 2020
Xa inhibitor
44
Condition caused by acquired inhibition of hepatic uroporphyrinogen decarboxylase activity ## Footnote ACP September 2020
Porphyria cutanea tarda
45
Target hemoglobin level for patients with sickle cell disease undergoing moderate-risk surgery ## Footnote ACP September 2020
10 g/dL
46
Test of peripheral blood that can identify cell type by patterns of surface antigen expression ## Footnote ACP November 2020
Flow cytometry
47
The two hallmark findings of thrombotic thrombocytopenic purpura ## Footnote ACP November 2020
Microangiopathic hemolytic anemia and thrombocytopenia
48
Difference between the terms 'folate' and 'folic acid' ## Footnote ACP November 2020
Folate is the natural form of the vitamin, folic acid is the synthetic, therapeutic form (accept synthetic or therapeutic)
49
Meaning of 'wet purpura' ## Footnote ACP November 2020
Hemorrhagic blisters in mucous membranes, such as the oral mucosa
50
Most common drug associated with hemolytic anemia ## Footnote ACP November 2020
Piperacillin
51
Acronym describing acute respiratory distress, elevated B-type natriuretic peptide level, and elevated central venous pressure within 6 hours of transfusion ## Footnote ACP December 2020
TACO (Transfusion–associated circulatory overload)
52
Condition resulting from IgG autoantibodies directed against platelet membrane glycoproteins ## Footnote ACP December 2020
Primary immune thrombocytopenia (accept ITP, idiopathic thrombocytopenic purpura, immune thrombocytopenic purpura)
53
Two direct oral anticoagulants approved as initial therapy without heparin for venous thromboembolism disease ## Footnote ACP December 2020
Apixaban and rivaroxaban
54
A syndrome defined by the occurrence of two or more immune cytopenias ## Footnote ACP December 2020
Evans syndrome
55
Diagnosis accounting for absence CD55 and CD59 on red cells and granulocytes ## Footnote ACP December 2020
Paroxysmal nocturnal hemoglobinuria
56
The most common of the four acute porphyrias ## Footnote ACP April 2018
Acute intermittent porphyria
57
Major antibody-related complication of hemophilia ## Footnote ACP April 2018
Inhibitors to factor VIII or IX (accept inhibitors)
58
Condition characterized by inheritance of only one functional alpha globin chain ## Footnote ACP April 2018
Hemoglobin H
59
Name of units used to measure coagulation inhibitor titers ## Footnote ACP April 2018
Bethesda
60
Monoclonal antibody effective in the treatment of complement-mediated hemolytic uremic syndrome ## Footnote ACP April 2018
Eculizumab
61
Cause of splenomegaly and hepatomegaly in myelofibrosis (myeloid metaplasia) ## Footnote ACP July 2018
Extramedullary hematopoiesis
62
Post-surgical complication of bevacizumab therapy ## Footnote ACP July 2018
Delayed wound healing
63
In addition to fresh frozen plasma, a therapeutic source of fibrinogen ## Footnote ACP July 2018
Cryoprecipitate
64
Most specific morphological abnormality associated with myelodysplastic syndrome ## Footnote ACP July 2018
Ring sideroblasts
65
Otherwise known as Factor VI in the coagulation cascade ## Footnote ACP July 2018
Activated Factor V
66
Two most common sites of bleeding in hemophilia A
Joints and muscles
67
Eponym for Coombs-positive warm autoimmune hemolytic anemia and immune thrombocytopenia ## Footnote ACP November 2018
Evans syndrome
68
Most common cause of thrombocytosis >1,000,000/µL ## Footnote ACP November 2018
Infection
69
Anticoagulant associated with platelet clumping ## Footnote ACP November 2018
EDTA
70
Otherwise known as Factor IV in the coagulation cascade ## Footnote ACP November 2018
Calcium
71
A specific disease entity reflecting a deficiency of hematopoietic stem cells resulting in peripheral pancytopenia and bone marrow aplasia ## Footnote ACP January 2022
Aplastic anemia
72
Antibody type classically associated with warm autoimmune hemolytic anemia ## Footnote ACP January 2022
IgG
73
Initial medical therapy for patients with thrombocytosis-associated stroke ## Footnote ACP January 2022
Aspirin and cytoreductive therapy (accept hydroxyurea, anagrelide, or pegylated interferon for cytoreductive therapy)
74
Diagnosis associated with absence of the GPI anchor on two hematopoietic cell lines ## Footnote ACP January 2022
Paroxysmal nocturnal hemoglobinuria
75
Syndrome causing noninfectious fever and rash during the neutrophil recovery phase after autologous hematopoietic stem cell transplantation ## Footnote ACP January 2022
Engraftement syndrome
76
Term for the stacking of red blood cells on a peripheral blood smear ## Footnote ACP June 2023
Rouleaux (accept rouleaux formation)
77
Common term for the t(9;22) translocation in acute lymphoblastic leukemia ## Footnote ACP June 2023
Philadelphia chromosome
78
Autoantibodies directed toward complexes of herparin and this protein result in heparin-induced thrombocytopenia ## Footnote ACP June 2023
Platelet factor 4 (do not accept only platelet factor)
79
Elevation of this metabolic intermediate is associated with folate deficiency ## Footnote ACP June 2023
Homocysteine
80
Eponym for calculation using CBC parameters useful in differentiating iron deficiency anemia from thalassemia ## Footnote ACP June 2023
Mentzer index (accept erythrocyte count divided by the mean corpuscular volume)
81
Clinical condition most commonly associated with 'bite cells' on a peripheral blood smear ## Footnote ACP April 2023
Glucose-6-phosphate dehydrogenase deficiency (accept G6PD deficiency)
82
Hereditary hemochromatosis is most commonly associated with a mutation in this gene ## Footnote ACP April 2023
HFE (accept C282Y)
83
Medication with indications for treatment of acute promyelocytic leukemia and acne ## Footnote ACP April 2023
Tretinoin (accept all-trans retinoic acid, ATRA)
84
Eponym for triad of iron deficiency anemia, dysphagia, and esophageal webs ## Footnote ACP April 2023
Plummer-Vinson syndrome (Accept Paterson-Brown-Kelly Syndrome or sideropenic dysphagia)
85
Scoring system to predict severity of ADAMTS deficiency in suspected thrombotic thrombcytopenic purpura ## Footnote ACP April 2023
PLASMIC Score
86
A thrombotic microangiopathy caused by severely reduced activity of ADAMTS13 ## Footnote ACP August 2022
Thrombotic thrombocytopenic purpura (accept TTP)
87
Diagnosis most strongly suggested by widely variable and random changes in serial platelet counts ## Footnote ACP August 2022
Pseudothrombocytopenia
88
Thalassemia syndrome associated with 2 normal alpha globin chain genes ## Footnote ACP August 2022
Alpha thalassemia trait
89
Myelodysplastic disorder that classically presents in older women with refractory macrocytic anemia and normal platelet count ## Footnote ACP August 2022
Isolated del(5q) (accept 5 q syndrome)
90
Monoclonal antibody to treat Waldenström macroglobulinemia ## Footnote ACP August 2022
Rituximab
91
Factor that carries factor VIII in the circulation ## Footnote ACP April 2013
von Willebrand factor
92
Four vitamin K dependent coagulation factors ## Footnote ACP April 2013
II, VII, IX, and X (name all)
93
A metalloproteinase that is deficient in TTP ## Footnote ACP April 2013
ADAMTS 13
94
Intervention that decreases recurrent stroke in sickle cell disease ## Footnote ACP April 2013
Exchange transfusion
95
Cause of splenomegaly and hepatomegaly in myelofibrosis (myeloid metaplasia) ## Footnote ACP April 2013
Extramedullary hematopoiesis

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