Haematology Formative

Question 1

Where is the genetic change in Polycythaemia Rubra Vera?

Answer 1

JAK2 gene

Question 2

Seronegative arthropathy associated with Polycythaemia Rubra Vera?

Answer 2

Gout

Question 3

What disorder is characterised by overproduction of normally functioning blood cells?

Answer 3

Polycythaemia Rubra Vera

Rubra Vera- Very Red- Loadsa RBCs

Question 4

Treatment of Autoimmune Haemolytic Anaemia? (2)

Answer 4

Steroids

Folic Acid

Question 5

Name an ADP antagonist

Answer 5

Clopidogrel

antagonising ADP prevents platelet aggregation

Question 6

What is the mechanism of Clopidogrel?

Answer 6

Antagonises ADP, preventing platelet aggregation

Question 7

Prolonged clotting time, acquired reduction in coagulation factors, thrombocytopenia. What is this?

Answer 7

Consumptive coagulopathy

Likely DIC

Question 8

Isolated prolonged partial thromboplastin time suggests deficiency of factors involved in which coagulation pathway?

Answer 8

Intrinsic

Question 9

Hypersegmented neutrophils are nearly entirely pathognomic of what?

Answer 9

Pernicious anaemia

Question 10

Point mutation in beta globin chain causes what?

Answer 10

Sickle cell anaemia

Question 11

Sickle cell anaemia is caused by what genetic change?

Answer 11

Point mutation in beta globin chain

Question 12

Drug that specifically targets Tyrosine Kinase BCR-ABL

Answer 12

Imatinib