p Assmedicine Flashcards
Electrolyte side effect of SSRIs in the elderly?
Hyponatraemia
Secondary to SIADH
Deja Vu post seizure suggests the seizure focus was where?
Temporal Lobe
What ion channel is stimulated by Insulin to decrease blood potassium?
Na+/K+ ATPase pump
NaKA-mura gets it IN the net 🍀
Commonest method of Septic Arthritis spread?
Haematogenous
What binds free Haemoglobin?
Haptoglobin
Paraesthesia with seizure suggest the seizure focus is in which lobe?
Parietal
What drug is used in prophylaxis of Sickle Cell Crisis?
Hydroxyurea
Increases HbF preventing sickling
Hydroxyurea causes an increase in what?
Foetal Haemoglobin, HbF
Which drug increases levels of Foetal Haemoglobin?
Hydroxyurea
Thrombotic Thrombocytopenic Purpura (TTP) is due to failure of what?
Von Willebrand Factor cleavage
VWF multimers are also extra large in this disease
On what ion channel to Barbiturates and Benzodiazepines work?
Chloride ion channels
Barbiturates do what to Chloride ion channels?
Increase duration of opening
Tongs FREQUENtly BENd | DURing BARBecues 🍴🍳
Benzos- ↑ Frequency | Barbs- ↑ Duration of opening
Benzodiazepines do what to Chloride ion channels?
Increase frequency of opening
Tongs FREQUENtly BENd | DURing BARBecues 🍳🍴
Benzos- ↑ Frequency | Barbs- ↑ Duration of opening
What nerve innervates the pupillary sphincter?
CNIII Oculomotor
Can you diagnose Gout if a patient’s Urate is normal?
Yes! Often the case
What translocation is the Philadelphia Chromosome?
t 9;22
Assoc with CML
On what side does a unilateral cerebellar lesion cause signs?
Ipsilaterally
Same side!
What electrolyte tends to be low alongside Calcium?
Magnesium
What part of the RAAS system triggers ADH release?
Angiotensin II
Which drug is given for alcohol withdrawal first line?
Chlordiazepoxide, as long as it’s tolerated (long acting)
Lorazepam if hepatic failure (short acting)
Which drug is given for alcohol withdrawal with Hepatic Failure?
Lorazepam (short acting benzodiazepine)
Is Chlordiazepoxide a long acting or short acting drug?
Long acting benzodiazepine
Is Lorazepam a long acting or short acting drug?
Short acting benzodiazepine
What is the most common cause of Erythema Multiforme?
Herpes Simplex Virus HSV
What is the brand name of Dimethyl Fumarate used commonly for Multiple Sclerosis?
Tecfidera
What drug is the brand Tecfidera, and what does it treat?
Dimethyl Fumarate Multiple Sclerosis (disease modifying)
What drugs can cause Osteonecrosis of the Jaw?
Bisphosphonates
Denosumab
(both for Osteoporosis)
At what level of stenosis is Carotid Endarterectomy indicated?
> 70%
