p Assmedicine Flashcards

1
Q

Electrolyte side effect of SSRIs in the elderly?

A

Hyponatraemia

Secondary to SIADH

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2
Q

Deja Vu post seizure suggests the seizure focus was where?

A

Temporal Lobe

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3
Q

What ion channel is stimulated by Insulin to decrease blood potassium?

A

Na+/K+ ATPase pump

NaKA-mura gets it IN the net πŸ€

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4
Q

Commonest method of Septic Arthritis spread?

A

Haematogenous

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5
Q

What binds free Haemoglobin?

A

Haptoglobin

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6
Q

Paraesthesia with seizure suggest the seizure focus is in which lobe?

A

Parietal

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7
Q

What drug is used in prophylaxis of Sickle Cell Crisis?

A

Hydroxyurea

Increases HbF preventing sickling

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8
Q

Hydroxyurea causes an increase in what?

A

Foetal Haemoglobin, HbF

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9
Q

Which drug increases levels of Foetal Haemoglobin?

A

Hydroxyurea

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10
Q

Thrombotic Thrombocytopenic Purpura (TTP) is due to failure of what?

A

Von Willebrand Factor cleavage

VWF multimers are also extra large in this disease

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11
Q

On what ion channel to Barbiturates and Benzodiazepines work?

A

Chloride ion channels

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12
Q

Barbiturates do what to Chloride ion channels?

A

Increase duration of opening

Tongs FREQUENtly BENd | DURing BARBecues 🍴🍳
Benzos- ↑ Frequency | Barbs- ↑ Duration of opening

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13
Q

Benzodiazepines do what to Chloride ion channels?

A

Increase frequency of opening

Tongs FREQUENtly BENd | DURing BARBecues 🍳🍴
Benzos- ↑ Frequency | Barbs- ↑ Duration of opening

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14
Q

What nerve innervates the pupillary sphincter?

A

CNIII Oculomotor

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15
Q

Can you diagnose Gout if a patient’s Urate is normal?

A

Yes! Often the case

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16
Q

What translocation is the Philadelphia Chromosome?

A

t 9;22

Assoc with CML

17
Q

On what side does a unilateral cerebellar lesion cause signs?

A

Ipsilaterally

Same side!

18
Q

What electrolyte tends to be low alongside Calcium?

A

Magnesium

19
Q

What part of the RAAS system triggers ADH release?

A

Angiotensin II

20
Q

Which drug is given for alcohol withdrawal first line?

A

Chlordiazepoxide, as long as it’s tolerated (long acting)

Lorazepam if hepatic failure (short acting)

21
Q

Which drug is given for alcohol withdrawal with Hepatic Failure?

A

Lorazepam (short acting benzodiazepine)

22
Q

Is Chlordiazepoxide a long acting or short acting drug?

A

Long acting benzodiazepine

23
Q

Is Lorazepam a long acting or short acting drug?

A

Short acting benzodiazepine

24
Q

What is the most common cause of Erythema Multiforme?

A

Herpes Simplex Virus HSV

25
Q

What is the brand name of Dimethyl Fumarate used commonly for Multiple Sclerosis?

A

Tecfidera

26
Q

What drug is the brand Tecfidera, and what does it treat?

A
Dimethyl Fumarate
Multiple Sclerosis (disease modifying)
27
Q

What drugs can cause Osteonecrosis of the Jaw?

A

Bisphosphonates
Denosumab

(both for Osteoporosis)

28
Q

At what level of stenosis is Carotid Endarterectomy indicated?

A

> 70%