p Assmedicine

Question 1

Electrolyte side effect of SSRIs in the elderly?

Answer 1

Hyponatraemia

Secondary to SIADH

Question 2

Deja Vu post seizure suggests the seizure focus was where?

Answer 2

Temporal Lobe

Question 3

What ion channel is stimulated by Insulin to decrease blood potassium?

Answer 3

Na+/K+ ATPase pump

NaKA-mura gets it IN the net 🍀

Question 4

Commonest method of Septic Arthritis spread?

Answer 4

Haematogenous

Question 5

What binds free Haemoglobin?

Answer 5

Haptoglobin

Question 6

Paraesthesia with seizure suggest the seizure focus is in which lobe?

Answer 6

Parietal

Question 7

What drug is used in prophylaxis of Sickle Cell Crisis?

Answer 7

Hydroxyurea

Increases HbF preventing sickling

Question 8

Hydroxyurea causes an increase in what?

Answer 8

Foetal Haemoglobin, HbF

Question 9

Which drug increases levels of Foetal Haemoglobin?

Answer 9

Hydroxyurea

Question 10

Thrombotic Thrombocytopenic Purpura (TTP) is due to failure of what?

Answer 10

Von Willebrand Factor cleavage

VWF multimers are also extra large in this disease

Question 11

On what ion channel to Barbiturates and Benzodiazepines work?

Answer 11

Chloride ion channels

Question 12

Barbiturates do what to Chloride ion channels?

Answer 12

Increase duration of opening

Tongs FREQUENtly BENd | DURing BARBecues 🍴🍳
Benzos- ↑ Frequency | Barbs- ↑ Duration of opening

Question 13

Benzodiazepines do what to Chloride ion channels?

Answer 13

Increase frequency of opening

Tongs FREQUENtly BENd | DURing BARBecues 🍳🍴
Benzos- ↑ Frequency | Barbs- ↑ Duration of opening

Question 14

What nerve innervates the pupillary sphincter?

Answer 14

CNIII Oculomotor

Question 15

Can you diagnose Gout if a patient’s Urate is normal?

Answer 15

Yes! Often the case

Question 16

What translocation is the Philadelphia Chromosome?

Answer 16

t 9;22

Assoc with CML

Question 17

On what side does a unilateral cerebellar lesion cause signs?

Answer 17

Ipsilaterally

Same side!

Question 18

What electrolyte tends to be low alongside Calcium?

Answer 18

Magnesium

Question 19

What part of the RAAS system triggers ADH release?

Answer 19

Angiotensin II

Question 20

Which drug is given for alcohol withdrawal first line?

Answer 20

Chlordiazepoxide, as long as it’s tolerated (long acting)

Lorazepam if hepatic failure (short acting)

Question 21

Which drug is given for alcohol withdrawal with Hepatic Failure?

Answer 21

Lorazepam (short acting benzodiazepine)

Question 22

Is Chlordiazepoxide a long acting or short acting drug?

Answer 22

Long acting benzodiazepine

Question 23

Is Lorazepam a long acting or short acting drug?

Answer 23

Short acting benzodiazepine

Question 24

What is the most common cause of Erythema Multiforme?

Answer 24

Herpes Simplex Virus HSV

Question 25

What is the brand name of Dimethyl Fumarate used commonly for Multiple Sclerosis?

Answer 25

Tecfidera

Question 26

What drug is the brand Tecfidera, and what does it treat?

Answer 26

``` Dimethyl Fumarate Multiple Sclerosis (disease modifying) ```

Question 27

What drugs can cause Osteonecrosis of the Jaw?

Answer 27

Bisphosphonates Denosumab (both for Osteoporosis)

Question 28

At what level of stenosis is Carotid Endarterectomy indicated?

Answer 28

>70%