Group 9 - Naloxone HCl

Question 1

Naloxone HCl

Drug Class?

Answer 1

Naloxone HCl Drug Class:

• Narcotic antagonist

Question 2

Naloxone HCl

Mechanism of Action (MOA)?

Answer 2

Naloxone HCl MOA:

• Inhibition at narcotic receptor sites
• Reverses respiratory depression secondary to narcotics

Question 3

Naloxone HCl

Indications?

Answer 3

Naloxone HCl Indications:

• Antidote for opioid poisoning
• May differentiate opiod-induced coma from other causes

Question 4

Naloxone HCl

Contraindications?

Answer 4

Naloxone HCl Contraindications:

• Hypersensitivity

Question 5

Naloxone HCl

Adverse Reactions?

Answer 5

Naloxone HCl Adverse Reactions:

• Withdrawal symptoms, especially in neonates (nausea, vomiting, diaphoresis, increased heart rate, hypotension or hypertension, tremors)
• Be prepared for combative patient after administration

Question 6

Naloxone HCl

Adult Dose?

Answer 6

Naloxone HCl Adult Dose:

• IV/IO, IM, SL, ET: 2.0 mg initial bolus IV or ET, may repeat every 2 minutes as necessary; titrate to effect.
• Intra-nasal: 1.0 mg each nostril using a mucosal atomizer device (MAD) for a total of 2 mg. May repeat every 2 minutes as necessary. Titrate to effect.

Question 7

Naloxone HCl

Pediatric Dose?

Answer 7

Naloxone HCl Pediatric Dose:

• Less than 5 years or 20kg: 0.1 mg/kg IV, ET, SL, SC, IO, IN
• Greater than 5 years or 20kg: 2 mg IV, ET, SL, SC, IO, IN

Question 8

Naloxone HCl

Onset of Action?

Answer 8

Naloxone HCl Onset of Action:

• IV - within 2 minutes

Question 9

Naloxone HCl

Peak Effects?

Answer 9

Naloxone HCl Peak Effects:

• Variable

Question 10

Naloxone HCl

Duration of Action?

Answer 10

Naloxone HCl Duration of Action:

• Approximately 45 minutes

Question 11

Naloxone HCl

AZ Drug Box Minimum Supply?

Answer 11

Naloxone HCl AZ Drug Box Minimum Supply:

• 10 mg