Group 8 - Magnesium Sulfate

Question 1

Magnesium Sulfate

Class?

Answer 1

Magnesium Sulfate Class:

• Electrolyte
• Tocolytic
• Smooth muscle relaxant

Question 2

Magnesium Sulfate

Mechanism of Action (MOA)?

Answer 2

Magnesium Sulfate MOA:

• Decreases myocardial and neuromuscular irritability
• Inhibition of muscular excitability

Question 3

Magnesium Sulfate

Indications?

Answer 3

Magnesium Sulfate Indications:

• Torsade de Pointes
• Hypomagnesemia
• Pre-term Labor (PTL)
• Pregnancy-induced hypertension (PIH, pre-eclampsia and/or eclampsia)
• Hyperreactive airway - severe asthma

Question 4

Magnesium Sulfate

Contraindications?

Answer 4

Magnesium Sulfate Contraindications:

• Use cautiously in patients with impaired renal function and pre-existing heart blocks (relative)

Question 5

Magnesium Sulfate

Adverse Reactions?

Answer 5

Magnesium Sulfate Adverse Reactions:

• CV: Hypotension, Flushing, Heart Block, Asystole
• Resp: Respiratory Depression
• CNS: Drowsiness, Hypothermia, Depressed Reflexes
• GI: Nausea

Question 6

Magnesium Sulfate

Adult Dose?

Answer 6

Magnesium Sulfate Adult Dose:

• Torsade de Pointes: 1 -2 G IV diluted in 50-100 ml NS or D5W over 1-2 minutes, followed by the same amount infused over 1 hour
• Hypomagnesemia: 1-2 G IV diluted in 50-100 ml NS or D5W over 5-60 minutes
• Resp/Asthma: 2 G IV diluted in 50 ml NS or D5W over 5-10 minutes
• Pre-term labor (PTL): 4-6 G over 15-20 minutes
• PIH, pre-eclampsia, eclampsia: 3-6 G over 10-15 minutes

Question 7

Magnesium Sulfate

Onset of Action?

Answer 7

Magnesium Sulfate Onset of Action:

• Seconds
• 20 minutes for IV infusion (respiratory)

Question 8

Magnesium Sulfate

Peak Effects?

Answer 8

Magnesium Sulfate Peak Effects:

• Not Known

Question 9

Magnesium Sulfate

Duration of Action?

Answer 9

Magnesium Sulfate Duration of Action:

• 24 hours or greater

Question 10

Magnesium Sulfate

AZ Drug Box Minimum Supply?

Answer 10

Magnesium Sulfate AZ Drug Minimum Supply:

• 5 G

Question 11

Magnesium Sulfate

Special Notes?

Answer 11

Magnesium Sulfate Special Notes:

• O₂ should be administered to patients receiving Magnesium Sulfate
• Evaluate cardiac status and ECG assessing for prolonged PR and widened QRS intervals
• Keep calcium chloride 10% 10ml available to reversed magnesium toxicity
• Eclampsia may occur up to six weeks after delivery