Group 2 - Dexamethasone Sodium Phosphate (Decadron)

Question 1

Dexamethasone Sodium Phosphate (Decadron)

Drug Class?

Answer 1

Dexamethasone Sodium Phosphate (Decadron)

Drug Class:

• Synthetic adrenocorticoid / glucocorticoid
• Anti-inflammatory

Question 2

Dexamethasone Sodium Phosphate (Decadron)

MOA?

Answer 2

Dexamethasone Sodium Phosphate (Decadron)

MOA:

• Improves lung function and myocardial performance
• Stabilization of cell membranes
• Increase in surfactant production
• Relaxation of bronchospasm

Question 3

Dexamethasone Sodium Phosphate (Decadron)

Indications?

Answer 3

Dexamethasone Sodium Phosphate (Decadron)

Indications:

• Reactive airway disease
• Anaphylaxis
• Cerebral edema (non-traumatic)

Question 4

Dexamethasone Sodium Phosphate (Decadron)

Contraindications?

Answer 4

Dexamethasone Sodium Phosphate (Decadron)

Contraindications:

• Hypersensitivity
• Preterm infants

Question 5

Dexamethasone Sodium Phosphate (Decadron)

Adverse Reactions?

Answer 5

Dexamethasone Sodium Phosphate (Decadron)

Adverse Reactions:

• Hypertension
• Hyperglycemia
• Sodium retention and potassium loss

Question 6

Dexamethasone Sodium Phosphate (Decadron)

Adult Dose?

Answer 6

Dexamethasone Sodium Phosphate (Decadron)

Adult Dose:

• Reactive airway disease, Anaphylaxis: 8 - 24 mg IV/IO/IM
• Cerebral Edema: 1 - 5 mg/kg IV/IO/IM

Question 7

Dexamethasone Sodium Phosphate (Decadron)

Pediatric Dose?

Answer 7

Dexamethasone Sodium Phosphate (Decadron)

Pediatric Dose:

• Reactive Airway Disease, Anaphylaxis: 0.25 - 0.5 mg/kg IV/IO/IM
• Cerebral Edema: 0.5 - 1.5 mg/kg IV/IO/IM

Question 8

Dexamethasone Sodium Phosphate (Decadron)

Onset of Action?

Answer 8

Dexamethasone Sodium Phosphate (Decadron)

Onset of Action:

• 4 - 8 hours

Question 9

Dexamethasone Sodium Phosphate (Decadron)

Peak Effects?

Answer 9

Dexamethasone Sodium Phosphate (Decadron)

Peak Effects:

• 6 - 12 hours

Question 10

Dexamethasone Sodium Phosphate (Decadron)

Duration of Action?

Answer 10

Dexamethasone Sodium Phosphate (Decadron)

Duration of Action:

• 24 - 72 hours

Question 11

Dexamethasone Sodium Phosphate (Decadron)

AZ Drug Box Minimum Supply?

Answer 11

Dexamethasone Sodium Phosphate (Decadron)

AZ Drug Box Minimum Supply:

• Optional: 8 mg