Group 10 - Ondansetron (Zofran)

Question 1

Ondansetron (Zofran)

Drug Class?

Answer 1

Ondansetron (Zofran) Drug Class:

• Antiemetic

Question 2

Ondansetron (Zofran)

Mechanism of Action (MOA)?

Answer 2

Ondansetron (Zofran) Mechanism of Action (MOA):

• Blocks serotonin 5-HT₃ receptors located in the CNS and in the peripheral nervous system on nerve terminals of the vagus nerve (cranial nerve X).

Question 3

Ondansetron (Zofran)

Indications?

Answer 3

Ondansetron (Zofran) Indications:

• Nausea and vomiting

Question 4

Ondansetron (Zofran)

Contraindications?

Answer 4

Ondansetron (Zofran) Contraindications:

• Hypersensitivity
• Caution in patients with hepatic impairment
• Avoid use in patients with long QT syndrome

Question 5

Ondansetron (Zofran)

Adverse Reactions?

Answer 5

Ondansetron (Zofran) Adverse Reactions:

• CNS: Headache, malaise, fatigue, dizziness
• CV: Chest pain, arrhythmias
• Resp: Hypoxia
• GI: diarrhea, constipation, abdominal pain
• Skin: Rash

Question 6

Ondansetron (Zofran)

Adult Dose?

Answer 6

Ondansetron (Zofran) Adult Dose:

• 4 - 8 mg slow IV push over 2 - 5 minutes
• 8 mg PO ODT (orally disintegrating tablet)

Question 7

Ondansetron (Zofran)

Pediatric Dose?

Answer 7

Ondansetron (Zofran) Pediatric Dose:

• (1 month to 12 years old)
  
  • Greater than 40 kg: 4 mg slow IV push over 2 - 5 minutes
  • Less than 40 kg: 0.1 mg/kg slow IV push over 2 - 5 minutes
  • 4 - 12 years old: 4 mg PO ODT (orally disintegrating tablet)

Question 8

Ondansetron (Zofran)

Onset of Action?

Answer 8

Ondansetron (Zofran) Onset of Action:

• 10 - 30 minutes

Question 9

Ondansetron (Zofran)

Peak Effects?

Answer 9

Ondansetron (Zofran) Peak Effects:

• Unknown

Question 10

Ondansetron (Zofran)

Duration of Action?

Answer 10

Ondansetron (Zofran) Duration of Action:

• Half-life is approximately 4 hours

Question 11

Ondansetron (Zofran)

AZ Drug Box Minimum Supply?

Answer 11

Ondansetron (Zofran) AZ Drug Box Minimum Supply:

• Optional: 4 mg