genome projects Flashcards

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1
Q

what are sequencing projects

A

to map the dna base sequence that make up the genes of an organism and map these genes on the individual chromosomes

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2
Q

how do we sequence 20000 genes

A

we use bioinformatics

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3
Q

what is bioinformatics

A

it is the science of collecting and analysing complex biological data such as genetic codes

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4
Q

what does it use

A

computers to read store and organise biological data at a much faster rate and also uses algorithims

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5
Q

what technique do we use to complete the dna base sequence of an organism

A

whole genome shot gun sequencing

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6
Q

what does this involve

A

rresearcher cutting dna into small easily sequenced sectionsand then use computer algoritihim

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7
Q

what do these algorithims do

A

thy allign overlapping segments to assemble the entire genome snd are constantly updated

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8
Q

what medical advances have been made

A

medical screening to identify certain diseases by identifying snps in the genetic code

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9
Q

what are saps

A

single based variations in the genome that are associated with disease and other disorders

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10
Q

what does medical screening allow

A

quick identification of individuals that have potential to develop a medical disorder and allow early intervention

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11
Q

what is greater importance to human knowledge

A

not the genes but the nature of the protiens that the genes code for

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12
Q

what are these protiens called

A

the proteome

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13
Q

what is proteome

A

all the protiens produced by a genome at a given time under specified conditions

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14
Q

why is sequencing dna in bacteria useful

A

it can help us identify genes that can be exploited and be used in toxic envirometns for cleaning pollutants

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15
Q

why is determining proteome of bacteria easy

A

the prokaryotes only have one circular piece of dna that is not associated with histones
and there is no non coding portions of dna

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16
Q

what has knowledge of pathogenic antigens proteome led to

A

used to develop vaccine against disease caused by these pathogens which can help produce an immune response by the b cells and trigger a secondary response

17
Q

why is it hard to translate our info of genome to proteomes

A

as genes have may sections of non coding introns and gene sthat relegulate other genes only 1.5% may actually code for genes

18
Q

what has gene sequencing allowed us to compare

A

the dan sequence between individuals and different species to see the evolutionary relationshup

19
Q

apart from genome wide comparison what other importance is there

A

it allows the sequence of amino acids in a polypeptide to be predicted and development of synthetic biology

20
Q

what is the human genome project

A

an international scientific project that has determined the sequence of bases in the human genome

21
Q

what application does this have

A

screen for mutated sequences in a person for cancer of disorders like huntington’s disease