Gene models 3 Flashcards
What 2 sections of the nephron does the connecting tubules connect?
The late distal and the cortical collecting duct
What is the overall effect of the late distal, connecting tubules and cortical collecting duct?
Concentration of urine
Reabsorption of Na+, H2O
Secretion of K+, H+
What 2 main cell types are the late dt and ccd composed of ?
Principal cells
Intercalated cells
Main role of the principal cells in late dt and ccd?
Na+ and H2O reabsorption
K+ and H+ secretion
Main role of intercalated cells in late dt and ccd?
H+, HCO3- secretion and reabsorption
What are intercalated cells sectioned into?
Alpha IC
Beta IC
What on the basolateral membrane in a principal cell provides the driving force for Na+?
Sodium potassium ATPase
Where is ENaC located?
On the apical membrane of the principal cell
What is the amount potassium lost through ROMK set by?
The Na+ reabsorption by ENaC
Role of ENaC
Sodium reabsorption
What is the role of Aquaporin 2, AQP3 and AQP4 in the principal cell?
Water control
AQP2 = water pore
AQP3&4 = water from principal cell travels out of these into interstitial fluid
What is the relationship between sodium and water?
Water always follows sodium
What disease comes as a result of a mutated AQP2? What are the symptoms?
Diabetes insipidus
Increased flow rate
What disease comes as a result of a mutated ENaC? What are the symptoms?
Liddle’s syndrome
Hypertension
What is Amiloride an example of ? Where does it target?
A diuretic
Epithelial sodium channel is targeted to reduce blood pressure
