Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

D2 Fall > Gen Path Exam 4 - Female Reproductive Pathology > Flashcards

Gen Path Exam 4 - Female Reproductive Pathology Flashcards

1
Q

Which disease?

Large anogenital warts; due to HPV 6 and 11

A

Condyloma acuminata

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Which disease?

Papillary, elevated or flat, rugose (wrinkled/creased)

A

Condyloma acuminata

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Which disease?

Key histologic feature is koilocytosis

A

Condyloma acuminata

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Angular nuclei with perinuclear clearing

A

Koilocytosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Which disease?

Not precancerous

A

Condyloma acuminata

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Which disease?

Tumors are from epithelium; caused by oncogenic strains of HPV

A

Cervical carcinoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Which disease has the following risk factors?

Persistent HPV infection w/ high risk subtypes (HRHPV)
Early age at first intercourse
Multiple sexual partners
Male partner with history of multiple partners
Smoking
Immunodeficiency

A

Cervical carcinoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What is the most important risk factor of Cervical carcinoma?

A

Persistent HPV infection with high risk HPV subtypes (HRHPV)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Cervical cancer is caused by __________

A

HRHPV

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Tropic for immature squamous cells of the transformation zone

A

HRHPV

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Which zone of the cervix?

Squamocolumnar junction of the endocervix and exocervix

A

Transformation zone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Which zone of the cervix?

Moves (everts) from endocervix at birth to exocervix in young adults

A

Transformation zone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Which zone of the cervix?

Everted columnar cells undergo metaplasia into immature squamous cells

A

Transformation zone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Which disease?

These infections are transient and eliminated within months by host immune response

A

HPV infection

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Which disease?

Low risk types remain as free episomal viral DNA and cause benign lesions, like condyloma

A

HPV infection

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What is the pathogenesis of persistent HPV infections with HRHPV types?

A

Viral integration -> viral oncoprotein E6 and E7 -> neoplasia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

What does E6 and E7 do?

A

E6 = inhibits p53
E7 = blocks CDKIs (cyclin-dependent kinase inhibitor)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

T/F: HPV infection alone is sufficient to cause cancer

A

FALSE; HPV infection alone is INSUFFICIENT to cause cancer

19
Q

Which disease?

Evolves from asymptomatic precancerous lesion that appears many years before invasive carcinoma

A

Cervical carcinoma

20
Q

What is the name of the precancerous cervical lesion?

A

Squamous intraepithelial lesion (SIL)

21
Q

Low or high grade SIL?

Does not progress directly to carcinoma; most regress; 10% progress to HSIL

A

Low grade SIL

22
Q

Low or high grade SIL?

Progress to carcinoma (10% over 10 yrs, so the majority don’t)

A

High grade SIL

23
Q

Early detection of SIL is done with what test?

A

Pap smear

24
Q

Most successful cancer screening test ever develop

A

Pap smear

25
Q

What are the cervical cancer screening guidelines?

A

21-65: pap smear every 3 yrs
30-65: can add HPV co-test or just HRHPV test every 5 yrs
>65: stop pap smears, unless never been screened or high risk SIL is present

26
Q

What is done after an abnormal pap smear?

A

Biopsy/curettage during colposcopy

27
Q

Application of what makes affected areas in the cervix appear whiter to help guide biopsy?

A

Dilute acetic acid

28
Q

How are high risk SIL and persistent low risk SIL treated?

A

Surgical excision (cone biopsy)

29
Q

If HPV negative, there is a very low risk of harboring ________

A

SIL

30
Q

Which disease?

May be invisible or exophytic

A

Cervical carcinoma

31
Q

Which disease?

Requires HPV infection AND mutations in tumor suppressor and oncogenes

A

Cervical carcinoma

32
Q

What are most cervical carcinomas?

A

Squamous cell carcinoma

33
Q

Which disease?

Surgery, radiation, and chemo may all be used depending on stage

A

Cervical carcinoma

34
Q

Which disease?

Prognosis depends on clinical stage; even with positive nodes, 50% 5 yr survival

A

Cervical carcinoma

35
Q

How is cervical cancer prevented?

A

HPV vaccine for 11-12 yr old boys and girls

36
Q

Which vaccine prevents HPV 6 and 11, as well as high risk types like 16 and 18?

A

Gardasil 9

37
Q

Which disease?

Usually small, develop below surface

A

Ovarian cysts

38
Q

Which disease?

Large ones may be palpable/painful; rupture causes intraperitoneal bleeding

A

Ovarian cysts

39
Q

Which disease?

Excess production of mostly androgens by multiple cystic follicles in ovaries

A

Polycystic ovarian syndrome

40
Q

Which disease?

Hirsutism (male hair pattern), oligomenorrhea, infertility, enlarged ovaries w/ small subcortical cysts

A

Polycystic ovarian syndrome

41
Q

Which disease has the following risk factors?

Nulliparity
Low parity
Family history
BRCA1 mutation

A

Ovarian cancer

42
Q

Which disease has the following symptoms?

Limited until widespread; may cause abdominal pain, swelling or ascites related to seeding of peritoneal cavity

A

Ovarian cancer

43
Q

What is a bloodmarker that has poor sensitivity and poor specificity as a screening test for ovarian cancer?

A

CA-125

44
Q

What is CA-125 valuable for monitoring in ovarian cancer?

A

Response to therapy

D2 Fall (37 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions