Galt-microbiota Flashcards
How do bacterial flagellum affect gut regulation
Stimulate TLR -5 on dendritic cells in mucosa. This induces nfkb and therefore il6, il23 cytokines which induce th17 differentiation
Why is th17 importnat especially at mucosal surfaces (cao et al 2012)
Rleease of il 17 induces pigr expression and upreg of iga
What do segmented filamentous bacteria do sfb
Increase IEC and also th17 response and therefore iga response
What is clostridium species role in galt
Stimulate fox p3 expressed t cells meaning increased t regs eg by the production of scfa like butyrate
What does tslp do which is promoted by bacteria
Induce b cell development in mucosa
What other substance other than tslp do nacteria upregulate for tolerance
RA which induces t reg expression causing tolernace
How does fox p3 t regs block ige (zhang 2007)
Il10 induces igg4 producing class seitching of b cells
These igg4 compete with ige for mast cells rerucing inflammation
