fong V Flashcards
in the loop of henle, is the transport in the thin segments active or passive?
passive
is transport of NaCl in the thick ascending limb active or passive?
active
what 2 things inhibit Na+/K+/Cl- cotransporter?
bumetanide and lasix
lack of water permeability results in what?
dilution of the luminal fluid
what is impaired in Bartter syndrome?
NaCl absorption
what drives NaCl uptake in the DT?
Na+ gradient
what inhibits the Na+/Cl- cotransporter?
chlorothiazide (diuril)
distal tubular Ca2+ absorption is regulated by what?
PTH
PTH is released in response to what?
low plasma calcium
what types of cells are in the collecting ducts?
- principle cells
- alpha intercalated cells
- beta intercalated cells
what cells of the collecting duct absorb Na+ via ENaC?
principle cells
ENaC is regulated by what hormone?
aldosterone
what blocks Na+ absorption by inhibiting ENaC?
amiloride
water permeability of the collecting duct principle cells is modulated by what?
ADH
what water channel does ADH work on?
AQP2
what happens when the AQP@ and CD ADH-regulated H20 permeability loses it function because of mutation?
NEPHROGENIC diabetus insipidus
what are the signs of nephrogenic DI?
- inability to concentrate urine
- massive water diuresis
alpha intercalated cells secrete what?
acid (carnivores)
beta intercalated cells secrete what?
base (bicarb) (herbivores)
