fong V

Question 1

in the loop of henle, is the transport in the thin segments active or passive?

Answer 1

passive

Question 2

is transport of NaCl in the thick ascending limb active or passive?

Answer 2

active

Question 3

what 2 things inhibit Na+/K+/Cl- cotransporter?

Answer 3

bumetanide and lasix

Question 4

lack of water permeability results in what?

Answer 4

dilution of the luminal fluid

Question 5

what is impaired in Bartter syndrome?

Answer 5

NaCl absorption

Question 6

what drives NaCl uptake in the DT?

Answer 6

Na+ gradient

Question 7

what inhibits the Na+/Cl- cotransporter?

Answer 7

chlorothiazide (diuril)

Question 8

distal tubular Ca2+ absorption is regulated by what?

Answer 8

PTH

Question 9

PTH is released in response to what?

Answer 9

low plasma calcium

Question 10

what types of cells are in the collecting ducts?

Answer 10

• principle cells
• alpha intercalated cells
• beta intercalated cells

Question 11

what cells of the collecting duct absorb Na+ via ENaC?

Answer 11

principle cells

Question 12

ENaC is regulated by what hormone?

Answer 12

aldosterone

Question 13

what blocks Na+ absorption by inhibiting ENaC?

Answer 13

amiloride

Question 14

water permeability of the collecting duct principle cells is modulated by what?

Answer 14

ADH

Question 15

what water channel does ADH work on?

Answer 15

AQP2

Question 16

what happens when the AQP@ and CD ADH-regulated H20 permeability loses it function because of mutation?

Answer 16

NEPHROGENIC diabetus insipidus

Question 17

what are the signs of nephrogenic DI?

Answer 17

• inability to concentrate urine

- massive water diuresis

Question 18

alpha intercalated cells secrete what?

Answer 18

acid (carnivores)

Question 19

beta intercalated cells secrete what?

Answer 19

base (bicarb) (herbivores)