Final: Vascular Development Flashcards
The hematopoietic lineage is influenced by _____.
Runx-1
The endothelial lineage is influenced by _____.
Hoxa-3
When does hematopoiesis begin in the liver?
Weeks 5-6 of gestation
What is the pathway of hematopoiesis in the fetus?
Primitive streak–>Yolk sac–>Fetal liver–>Bone marrow
T/F: Yolk sac RBCs are non-nucleated.
False, Liver RBCs are non-nucleated. Yolk sac RBCs have large nuclei
When does blood cell formation switch to bone marrow and what controls the switch?
Month 6
Cortisol
What are the types of chains in the 4 hemoglobin stages in humans? Early (Gower 1)? Early (Gower 2)? Fetal? Adult?
Early (Gower 1): zeta/epislon
Early (Gower 2): alpha/epsilon
Fetal: alpha/gamma
Adult: alpha/beta
What are the types of chains in the 4 hemoglobin stages in humans? Early (Gower 1)? Early (Gower 2)? Fetal? Adult?
Early (Gower 1): zeta/epislon
Early (Gower 2): alpha/epsilon
Fetal: alpha/gamma
Adult: alpha/beta
What is vasculogenesis?
Recruitment of angioblasts
VEGFR-2 appears on _____, while VEGF-A appears on _____
Membrane surfaces.
Surrounding mesenchyme
Angiopoietin-1 & Tie-2 and Notch signaling pathways contribute to _____.
Sprouting
What stimulates immigration of mesenchymal cells to build a vascular wall?
Platelet-derived growth factor
Signaling for arteries to differentiate involves which signaling pathways?
Shh & Notch
What ligand is expressed in developing arteries?
Ephrin-B2
What ligand is expressed in developing veins?
Eph-B4
The venous pathway is initiated via _____.
COUP-TFII
The lymphatics require _____ followed by _____.
Sox-18.
Prox-1
Which pair of aortic arches form the internal carotids?
Third
Which pair of aortic arches become associated with the pulmonary system?
Sixth
Which aortic arch in mammals forms the adult aortic arch?
Fourth
Which aortic arch in mammals forms the adult aortic arch?
Fourth
Which cardinal veins form the internal jugulars?
Anterior cardinals
How is blood from the head drained?
Right cardinal vein–>Superior vena cava
How is blood from the head drained?
Right cardinal vein–>Superior vena cava
The inferior vena cava is built from remnants of…?
Vitelline vein, Subcardinals, Supracardinals, & Iliacs
