Final: Eye Develoment Flashcards

1
Q

Development of the preplacodal region involves activation of _____ pathway & inhibition of _____ & _____.

A

FGF.

Wnt & BMP

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2
Q

Arrange the following in order of least to highest concentration with increasing BMP concentration.
Neural plate
Placodes
Neural crest

A

Placodes, Neural crest, Neural plate

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3
Q

The optic stalk forms the _____.

A

Optic vesicle

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4
Q

The _____ artery uses the _____ _____ & _____ _____ to pass into the posterior chamber of the eye.

A

Hyaloid
Choroid fissure
Optic stalk

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5
Q

Absence of the Pax6 gene in mammals results in…?

A

Early optic vesicle formation, but not rest of eye

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6
Q

Absence of the Pax6 gene in mammals results in…?

A

Early optic vesicle formation, but not rest of eye

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7
Q

High concentrations of _____ inhibit Pax6 expression.

A

Shh

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8
Q

Shh is in high concentrations in the _____ (distal/proximal) part of the eye and induces expression of Pax2.

A

Proximal

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9
Q

T/F: Lens fiber cells are postmitotic.

A

True

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10
Q

_____ accumulate in the vitreous humor and stimulate formation of lens fibers.

A

FGF

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11
Q

What is the iris derived from?

A

Pigmented layer of retina

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12
Q

What is the term for absence of an eye resulting from a mutation in RAX, attributed to lack of formation of the optic vesicle?

A

Anophthalmos

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13
Q

What is the term for an eyeball that is slightly smaller or almost vestigial (compared to the normal one) and is associated with intrauterine infections & rubella syndrome?

A

Microphthalmos

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14
Q

What is the term for nonclosure of the choroid fissure of the iris during the 6th or 7th week of development?

A

Coloboma of the Iris

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