Exam 3: Nervous System Development III

Question 1

What areas of the brain have additional gray matter on top of the white matter tracts?

Answer 1

Cerebrum & cerebellum

Question 2

A true _____ consists of multiple layers of gray matter and is built from the inside out.

Answer 2

Cortex

Question 3

_____ _____ cells are located in the ventricular zone and extend all the way to the surface of the brain.

Answer 3

Radial glial

Question 4

Abnormalities of radial glial cells in the cerebellum causing abnormal migration and granular layering is called?

Answer 4

Weaver

Question 5

Abnormal/absence of cortical layering is due to _____.

Answer 5

Reeler

Question 6

What protein has been shown to be defective in Reeler mutant mice?

Answer 6

Reelin

Question 7

GET SOMEONE TO SEND YOU BOX 11.1

Answer 7

GET SOMEONE TO SEND YOU BOX 11.1

Question 8

Pronounced expansion of the roof plate to form the thin roof over the 4th ventricle is the major topographical change of the _____.

Answer 8

Myelencephalon

Question 9

Expression of which genes is responsible for differentiation of specific nuclei in the myelencephalon?

Answer 9

Hox genes

Question 10

What are the major derivatives of the metencephalon?

Answer 10

Pons & cerebellum

Question 11

Induction of the roof plate and neural tube via BMP signaling in the metencephalon causes the _____ to form in the region of the _____ _____.

Answer 11

Cerebellum.

Rhombic lips

Question 12

What are massive fiber bundles between the cerebellum & mesencephalon?

Answer 12

Superior cerebellar peduncles.

Question 13

_____ cells migrate anteriorly along dorsal region of rhombomere 1 and interiorly through the purkinje layer.

Answer 13

Granule

Question 14

_____ cells migrate radially through granule cells.

Answer 14

Purkinje

Question 15

What are the major derivatives of the alar plates of the mesencephalon?

Answer 15

Superior/inferior colliculi

Question 16

What confines Shh to the basal part of the midbrain?

Answer 16

Otx-2

Question 17

What is the function of cerebral peduncles?

Answer 17

Carry fibers between hemispheres & spinal cord

Question 18

What are the 3 patterning centers in the forebrain and what signal molecules are involved with them?

Answer 18

Rostral: FGF-8
Dorsal: BMPs & Wnts
Ventral: Shh

Question 19

What is a closure feature of the spinal cord called?

Answer 19

Rachischisis

Question 20

Closure defects can be diagnosed by elevated levels of _____ in the amniotic fluid.

Answer 20

Alpha-fetoprotein