Final: Urinary System Development Flashcards
T/F: The mesonephric duct becomes the pronephric duct.
False, pronephric becomes mesonephric
_____ mesoderm is the source of mesenchyme for urinary/reproductive formation.
Intermediate
What is the functional unit of the kidney?
Tubule/Nephron
What transcription factors induce Lim-1 which causes mesenchymal cells to aggregate into pronephric ducts?
Pax-2 & Pax-8
What is the functional kidney in most vertebrate embryos, including humans?
Mesonephros
Mesonephric tubules are _____ than pronephric tubules and often _____ in shape.
Longer,
Sigmoid/convoluted
The development of the mesonephric tubules is dependent on the presence of the _____.
Pronephric duct
What regulates the transformation of the intermediate mesodermal mesenchyme to epithelium?
WT-1
What regulates the transformation of the intermediate mesodermal mesenchyme to epithelium in the mesonephros?
WT-1
What initiates the formation of the metanephric kidney (final kidney)?
Ureteric bud
What gives rise to the adult ureter, renal pelvis, & collecting tubules?
Metanephric diferticulum
The mesenchyme surrounding the metanephric diverticula condense into _____ and form the renal tubules of the adult kidney.
Blastemata
The mesenchyme surrounding the metanephric diverticula condense into _____ and form the renal tubules of the adult kidney.
Blastemata
_____ inhibits ureteric bud formation in certain areas while _____ inhibits _____ in places ureteric bud is supposed to form.
BMP.
Gremlin, BMP
What makes the ureter epithelium impermeable to water?
Uroplakins
What is termed the absence of any trace of kidney tissue?
Renal agenesis
What is the term for bilateral renal agenesis which exhibits flattened nose, wide interpupillary space, receding chin, tapering fingers, low-set ears, hip dislocation, & pulmonary hypoplasia?
Potter sequence
What is the term for bilateral renal agenesis which exhibits flattened nose, wide interpupillary space, receding chin, tapering fingers, low-set ears, hip dislocation, & pulmonary hypoplasia?
Potter sequence
What is the term for an intermediate between renal agenesis and normal kidney function?
Renal hypoplasia
What is the term for kidneys that are fused at their inferior poles and are incapable of migrating out of the pelvic cavity due to the inferior mesenteric artery?
Horseshoe kidney
What is the term for formation of tons of cysts of different sizes within the parenchyma of the kidney?
Polycystic disease of the kidney
What is a major defect in which the urinary bladder opens through the abdominal wall?
Exstrophy of the bladder
