Final: Chapter 14- Host Immunity Part 1 Flashcards
What are the three levels of the hot defense system? Know the basics of what occurs at each level.
1st level is barriers
2nd line of defense is innate immunity which occurs through phagocytosis, inflammation, fever, and antimicrobial proteins
3rd line of defense is specific immunity
What are the 4 types of innate immune responses?
1) phagocytosis
2) inflammation
3) fever
4) antimicrobial proteins
Why are macrophages considered antigen presenting cells?
They phagocytosize pathogens and display their antigens on their surface
What are the 3 types of specialized macrophages and where would each be found in its respected location in the body?
Alveolar = lungs Kupffer= liver Dendritic= skin
What are the 3 general activities of phagocytes?
1) chemotaxis and indigestion
2) phagolysosome formation
3) destruction and excretion
Generally speaking, how does the body distinguish “self vs no self”?
Cell surface markers
In general, what is an inflammatory response?
A reaction to any traumatic event in the tissue
What are the primary functions of inflammation?
1) mobilize and attract immune components to the site of the injury
2) set in motion mechanisms to repair tissue damage and localized and clear away harmful substances
3) destroy microbes and block their further invasion
What are vasoactive mediators and chemotactic factors?
Vasoactive mediators affect the blood vessels
Chemotactic factors affect WBCs
What do the terms diapedesis and chemotaxis mean?
Diapedesis= process by which WBCs adhere to inner walls of smaller blood vessels and migrate out of the vessels into the tissue spaces
Chemotaxis= tendency of cells to migrate in response to a specific chemical stimulus given off at a site of injury infection
What is a pyrogen? How are endogenous pyrogens different from exogenous pyrogens and what component of gram-negative bacteria can serve as an exogenous pyrogen?
Pyrogens are fever inducing molecules.
Exogenous originate outside the body.
Endogenous originate inside the body.
The component that causes them is endotoxin
What are the 3 general benefits of fever?
1) inhibits multiplication of temperature-sensitive microorganisms
2) impedes the nutrition of bacteria by reducing the availability of iron
3) increases metabolism and stimulates immune reactions and naturally protective physiological processes