Facelift - Browlift Flashcards
A 55-year-old woman comes to the office to discuss a facelift. A rhytidectomy with SMASectomy (superficial musculoaponeurotic system) is planned. Compared with a skin-only facelift, a SMAS tightening procedure is associated with a decrease in which of the following?
A) Facial nerve injury
B) Hematoma formation
C) Infection rate
D) Longevity of result
E) Tension on the skin closure
The correct response is Option E.
When superficial musculoaponeurotic system (SMAS) tightening procedures are performed, the tension of the facelift is secured at the SMAS level rather than the skin. With a skin-only facelift, the lift must depend solely on the skin sutures for support. The more tension on the skin, the more likely a spread or hypertrophic scar will occur.
SMAS procedures do not decrease the longevity of results. Many surgeons believe that a SMAS facelift will produce better results and longer lasting results. Despite these opinions, there are no conclusive evidence-based studies to prove an increase in longevity of results.
Hematoma formation is related to hypertension and extent of dissection, not whether a SMASectomy was performed.
SMAS procedures put the facial nerve at greater danger than skin-only facelifts. The incidence of facial nerve injury is low with both techniques.
Infection rates are low with both procedures.
A 57-year-old woman comes to the office because she is dissatisfied with the appearance of her eyes. She says they appear “small” and “tired.” Physical examination shows dermatochalasis of the upper eyelids, 2 mm of eyelid ptosis, deep transverse rhytides of the forehead, and fine periorbital rhytides. She elevates her eyebrows 3 mm when she opens her eyelids. A skin-only blepharoplasty with formal eyelid ptosis repair is planned. After the procedure, which of the following clinical findings is most likely in this patient?
A) Blepharospasm
B) Brow ptosis
C) Decreased pretarsal show
D) Decreased volumetric convexity
E) Eyelid retraction
Correct answer is option B.
A patient who undergoes blepharoplasty and ptosis repair in the context of a compensated brow ptosis is likely to experience worsened brow ptosis after the procedure. Evaluation of the blepharoplasty patient requires careful examination of the entire upper third of the face. Patients may have, in addition to excess upper eyelid skin, an eyelid ptosis. In addition to identifying the ptosis, it is important to recognize compensated brow ptosis. A compensated eyelid ptosis occurs when the patient uses the frontalis muscles to raise the eyebrows, which results in a functional improvement in visual fields. This is most easily identified by having the patient close her eyes, and evaluate the automatic raising of the eyebrow on eyelid opening. In this case, the change in the position of the brow on downward gaze and on frontal gaze indicates a compensated brow ptosis. After ptosis repair and blepharoplasty, brow ptosis can become more manifest as the need for compensation decreases.
A 50-year-old woman returns to the office 2 weeks after undergoing an endoscopic brow lift and reports numbness in the central forehead. Which of the following nerves is most likely injured?
A) Frontal branch of the facial
B) Infraorbital
C) Supraorbital
D) Zygomaticofacial
E) Zygomaticotemporal
The correct response is Option C.
Central forehead paresthesias are typically related to traction injury to the supraorbital nerve, a division of ophthalmic (V1) nerve. The supraorbital and supratrochlear nerves supply the central forehead. The frontal branch of the facial nerve is a motor nerve to the frontalis muscle and, although at risk during brow lift, it has no sensory supply. The zygomaticotemporal nerve supplies the anterior temporal area. The zygomaticofacial nerve supplies the skin of the lateral orbit and cheek. The infraorbital nerve supplies the central face and upper lip.
A 47-year-old woman with moderate jowling and minimal cervical skin redundancy undergoes a minimal access cranial suspension (MACS) lift. Which of the following is the most appropriate description of the management of this patient’s superficial musculoaponeurotic system (SMAS)?
A ) Anchoring to the zygomatic arch
B ) Division and excision
C ) Elevation and rotation to the mastoid
D ) Purse-string suturing to the deep temporal fascia
E ) Suspension to the orbital rim
The correct response is Option D.
In a MACS lift, the SMAS is purse-string sutured to the deep temporal fascia. The MACS lift is a short scar rhytidectomy technique that elevates the deep tissues and skin using a vertical vector only. The skin flap is elevated through a preauricular and pretemporal hairline incision only. Following elevation of the skin, the deep facial tissues are suspended using purse-string sutures into the SMAS tissue. They are then anchored to the deep temporal fascia above the zygomatic arch, avoiding the facial nerve. In the simple MACS lift, two purse-string sutures are placed in the SMAS to correct the neck and lower third of the face. In the extended MACS lift, an additional third purse-string suture is placed in the SMAS to suspend the malar fat pad. As with the SMAS, a vertical vector is utilized to redrape and inset the skin.
Although there are many techniques for modification of the SMAS, the MACS lift does not involve SMAS plication, excision, elevation, or SMAS suspension to the zygomatic arch.
A 55-year-old woman comes to the office for facial rejuvenation surgery. Rhytidectomy with a high superficial musculoaponeurotic system flap and plication of the platysma are planned. In comparison with general anesthesia, the primary advantage of intravenous sedation in this patient is decreased risk for which of the following?
A) Deep venous thrombosis
B) Hematoma
C) Infection
D) Prolonged operative time
E) Skin necrosis
The correct response is Option A.
The risk for deep venous thrombosis (DVT) is decreased in many plastic surgical procedures when intravenous sedation is used instead of general anesthesia. Intravenous sedation avoids the need for muscle relaxant and the associated loss of peripheral vascular resistance.
Many rhytidectomy patients are at elevated risk for DVT; however, utilizing chemoprophylaxis will increase the hematoma risk and potentially jeopardize the final surgical result. Switching to an intravenous sedation technique is a safe and easy alternative for lowering DVT risk.
The incidence of hematoma, infection, and skin necrosis have not been linked with this type of anesthesia. Intravenous sedation can be associated with increased operative time for the rare patient who is resistant to sedation.
A healthy 68-year-old woman comes to the office because she is unhappy with the aged appearance of her forehead. She does not smoke cigarettes. Physical examination shows transverse rhytides across the forehead with deep glabellar creases. Forehead height is 11 cm. Which of the following is the most appropriate approach for brow lift surgery in this patient?
A) Endoscopic
B) Open coronal
C) Open pretrichial
D) Transpalpebral
The correct response is Option C.
Several factors should be considered in planning a brow lift surgery. Generally, as patients age, the face and forehead both elongate. In addition, a receding hairline can also contribute to a long forehead. The forehead, measured from the hairline to the brow, should be approximately one third of facial length. In most individuals, this falls somewhere between 6 and 10 cm. In the patient described, the forehead height is 11 cm, making her forehead slightly long.
Ptosis of the eyebrows may also occur in the aging process, and patients may compensate by using the frontalis muscle, which leads to deep transverse forehead rhytides. The corrugators depress the eyebrow, which leads to vertical glabellar lines. Often, patients with brow ptosis request blepharoplasty, and it is important for the clinician to recognize brow ptosis. This can be done by asking the patient to close his or her eyes and open them slowly. Automatic brow elevation with frontalis activation suggests brow ptosis.
The approach to forehead rejuvenation used depends on the forehead and brow findings in the individual patient. An open pretrichial incision shortens the forehead and is effective on deep rhytides. It is the most appropriate approach in the patient described. Endoscopic procedures are most useful for people with an optimal forehead length. This is due to the technical difficulty of using the endoscope across a long, convex surface. The coronal approach elongates the forehead, and, as such, it is used most commonly in patients with a short forehead. A transpalpebral corrugator resection is most useful for patients with no eyebrow ptosis.
In a patient who has a prominent anterior platysmal band, which of the following is the most appropriate operative management?
(A) Direct excision
(B) Lateral SMAS advancement
(C) Midline plication
(D) Suction lipectomy
(E) Z-plasty
The correct response is Option C.
Platysmal bands, which were first described more than half a century ago, are often a source of dissatisfaction in patients undergoing rhytidectomy, usually because they are treated inadequately and often recur. Anatomic studies of the platysma have shown a varying pattern of midline decussation as well as medial and lateral pleating caused by laxity of the muscle, which occurs with aging. Consequently, midline mobilization and plication of the muscle through a submental incision is most appropriate for management. In this procedure, a hammock is created, and there is no residual anterior banding. The platysmal bands should be marked with the patient in a sitting position. In patients who have severe lateral banding, a lateral SMAS plication can be performed in addition to the midline plication, but if it is too tight, it will then result in dehiscence of the central plication.
A recent study of 200 patients showed a reoperative rate of only 2.5% in patients who underwent midline plication; bowstringing was seen in only 1.5% of patients who underwent treatment with this method. Complications included hematoma (4%), scar revision (3.5%), and infection (2.5%).
Direct excision of the bands has had varying results but, in most cases, is inadequate as the sole treatment. This technique results in the formation of a new edge, but the muscle does not tighten with animation.
Platysmal bands were treated historically with lateral advancement of the SMAS alone; however, the results were often disappointing. Division of the platysma horizontally above the thyroid cartilage also had undesirable results, leading to a “skeletonized” appearance of the neck, and making the thyroid cartilage more prominent.
Suction lipectomy is effective for removal of the submental fat but cannot be used to remove muscle and therefore is not appropriate management of an anterior platysmal band. Z-plasties of the skin and muscle will not change the redundancy and dynamic appearance of the platysmal band; instead, they will result in conspicuous scarring and will not sufficiently change the muscular sling.
A 55-year-old woman has numbness at the frontoparietal scalp following a rhytidectomy and endoscopic brow lift. The numbness is most likely the result of injury to which of the following nerves?
A ) Auriculotemporal
B ) Frontal branch of the facial nerve
C ) Supraorbital
D ) Supratrochlear
E ) Zygomaticotemporal
The correct response is Option C.
The supraorbital nerve has two divisions. The superficial division supplies sensation to the central forehead and hairline. The deep division supplies sensation to the central frontoparietal scalp. The supratrochlear nerve supplies sensation to the nasal radix and part of the central forehead. Both of these nerves are at risk of injury during resection of the corrugator muscles.
The auriculotemporal nerve and zygomaticotemporal nerve supply sensation to the temporal scalp. The frontal branch of the facial nerve is a motor nerve and does not have any sensory function.
A 65-year-old man presents for initial consultation for rhytidectomy. BMI is 32 kg/m2. Blood pressure is 145/85 mmHg, and hemoglobin A1c concentration is 6.4%. Rhytidectomy with neck lift under local anesthesia and sedation is planned. Which of the following treatments would most likely minimize the risk for hematoma?
A) Clonidine
B) Hypotensive anesthesia
C) Lidocaine with epinephrine
D) Metformin
E) Self-suction drain
The correct response is Option A.
Perioperative hypertension is the single most important modifiable risk factor for preventing postoperative hematoma in rhytidectomy. Postoperative systolic blood pressure greater than 140 mmHg is strongly correlated with increased risk for hematoma. Clonidine is a long-acting ?2-adrenergic agonist used to decrease postoperative hypertension. This strategy has been shown to decrease hematoma rates. The usual dose is clonidine 0.1 to 0.3 mg orally 1 hour before surgery or a transdermal patch with 0.1 to 0.2 mg. The lower doses are usually given to women.
Metformin is used for diabetic control and not associated with hematoma risk. Self-suction drains can minimize the seroma rate but not the hematoma rate. Lidocaine with epinephrine and hypotensive anesthesia can both decrease intraoperative bleeding; however, they may add to the risks for hematoma after their effects have worn off.
A 59-year-old woman comes to the office for evaluation of rhytidectomy for facial aging. Use of a fibrin glue during rhytidectomy is planned. Which of the following is most commonly associated with use of tissue sealants after rhytidectomy?
A) Decreased ecchymosis
B) Decreased period of induration
C) Decreased scar formation
D) Increased drainage
E) Increased edema
The correct response is Option A.
Tissue sealants, such as fibrin tissue adhesives and platelet-rich plasma, have been utilized to affect drainage, ecchymosis, and edema following rhytidectomy. Prospective studies have demonstrated decreased rate of ecchymosis, edema, seroma, and prolonged induration. Although no major differences exist, studies have shown only a trend toward drainage reduction. Tissue sealants have not been shown to affect scar formation.
A 55-year-old woman comes to the office requesting treatment of fine rhytides due to smoking and photoaging. Topical retinoid therapy is planned. Which of the following effects is most likely to occur with topical retinoid treatment?
A) Decreased collagen production
B) Decreased hyaluronic acid production
C) Thinning of the dermis
D) Thinning of the epidermis
E) Thinning of the stratum corneum
The correct response is Option E.
Tretinoin (all-trans-retinoic acid) is one of the best long-term topical therapies available for chronically photoaged skin. Long-term use of tretinoin is associated with improved skin texture, decreased sallowness, a reduction in fine rhytides and actinic keratoses, fading of pigmented macules, and an overall improvement in skin appearance. Histologic effects of tretinoin include the following: increased epidermal and dermal layer thickness, elimination of dysplasia, atypia, and microscopic actinic keratoses, uniform dispersion of melanin granules, increased collagen and glycosaminoglycan deposition in the papillary dermis, diminished dermal elastosis, angiogenesis, and compaction/thinning of the stratum corneum.
The mechanism of action of retinoids is regulated through specific nuclear receptors. Ultraviolet radiation activates a series of phosphokinases that stimulate c-Fos and c-Jun proto-oncogenes, and thereby activate activator protein 1 (AP-1) transcription factor. AP-1 causes activation of metalloproteases, such as collagenase, gelatinase, and stromelysin which then break down collagen. Tretinoin results in a 70% inhibition of AP-1 transcription factor binding to DNA and a significant reduction in protease activity.
Tretinoin side effects include erythema, photosensitivity, and desquamation. Patients are initially started on a low dose with nightly application until tolerance is achieved. Because tretinoin is a photosensitizer, sunscreen use is absolutely imperative. Topical retinoids should be used for a minimum of 3 to 4 months, with the greatest improvement after 1 year of use. Patients who use alpha-hydroxy acids concomitantly with topical retinoids will see a synergistic effect and this combination is tolerated well in most patients.
Ten years after undergoing primary rhytidectomy, a 65-year-old woman is scheduled for a secondary rhytidectomy procedure. Which of the following complications is more likely to occur with this procedure than with the primary procedure?
(A) Distortion of the hairline
(B) Hematoma
(C) Hypertrophic scarring
(D) Skin laxity
(E) Skin slough
The correct response is Option A.
The most likely complication associated with secondary rhytidectomy is distortion of the hairline. Hairline shifts, especially in the temporal region, can result in difficulties with incision placement. Redraping of the facial skin superiorly can result in recession of the temporal hairline with elevation of the sideburn above the helical attachment. When planning a secondary rhytidectomy procedure, the anatomy of the hairline, ear lobes, and tragus should be analyzed.
The risk for hematoma is lower following a secondary procedure than following the initial surgery, as flap dissection and undermining are easier and associated with less blood loss. Because the facial skin is delayed following primary rhytidectomy, the vascular supply to the cervicofacial skin is usually healthy at the time of secondary rhytidectomy, and the risk for hypertrophic scarring or skin slough is minimal. Secondary skin flaps are also able to endure greater tension. Most of the contouring performed during secondary rhytidectomy involves tightening of the lax superficial fascia and not the already tightened facial skin. Therefore, the amount of excess skin removed during the repeat procedure will be less, and skin laxity will not be seen.
The temporal branch of the facial (VII) nerve is found at what level in the forehead above the zygomatic arch?
(A) Within the subcutaneous fat
(B) Deep to the superficial temporal fascia
(C) Deep to the deep temporal fascia
(D) Within the temporalis muscle
(E) Under the periosteum
The correct response is Option B.
The temporal (or frontal) branch of the facial (VII) nerve courses deep to the superficial temporal fascia in the lateral forehead, above the zygomatic arch, as depicted in the illustration above. This nerve innervates the frontalis muscle. It does not course through the temporalis muscle. It is important to avoid injuring the nerve during rhytidectomy procedures, as injury may result in the development of eyebrow ptosis.
A 65-year-old woman undergoes rhytidectomy using a high superficial musculoaponeurotic system technique. On examination 1 hour postoperatively, the patient is unable to raise her right eyebrow. No other abnormalities are noted. The patient’s family is anxious, and they want to call a neurologist. Which of the following is the most appropriate course of action at this time?
A) Administer intravenous corticosteroids
B) Consult a neurologist
C) Order nerve conduction studies
D) Reexamine the patient in 24 hours
E) Surgical reexploration
The correct response is Option D.
The high superficial musculoaponeurotic system (SMAS) technique, as described by Barton, divides the SMAS transversely at the superior-most portion of the zygomatic arch. Anatomical studies show that the procedure can be performed safely, as the frontal branch of the facial nerve runs in close proximity to the periosteum of the zygomatic arch, not within the SMAS, in the zone of SMAS transection.
The most common cause of facial nerve inactivity in this situation is related to the transient effects of local anesthesia injected during surgery. Reexamination once the effect of the local anesthesia has worn off is recommended. Intravenous corticosteroids, in a randomized controlled study, did not reduce facial edema, and would not benefit this patient. The diagnostic studies, neurology consult, and surgical reexploration are premature at this point in the patient’s course, but may be helpful later if there is no evidence of return of nerve function.
A 35-year-old woman comes to the office for evaluation and consultation regarding removal of wrinkles around the eyes and forehead, especially in the glabellar region. Physical examination shows that the lateral brow is slightly low. To raise the lateral brow using botulinum toxin (Botox) therapy, which of the following muscles must be treated?
A) Corrugator
B) Depressor supercilii
C) Frontalis
D) Orbicularis oculi
E) Procerus
Correct answer is option D.
The orbicularis oculi muscle is the primary depressor of the lateral brow. Therefore, paralysis of this muscle with botulinum toxin raises the lateral brow. Paralysis of the other muscles listed does not produce this effect. The corrugator muscle is responsible for producing vertical wrinkles in the glabellar area. The depressor supercilii muscle is the primary depressor of the medial brow. The frontalis muscle is the primary elevator of the brow. The procerus muscle is responsible for producing transverse wrinkles in the glabellar area.
A 67-year-old woman with marked lower facial and neck laxity is scheduled to undergo an extended superficial musculoaponeurotic system (SMAS) rhytidectomy. Excessive trimming of the skin flap adjacent to the base of the earlobe is most likely to result in which of the following outcomes?
A) Earlobe ptosis
B) Lop ear deformity
C) Pixie ear deformity
D) Reverse telephone ear deformity
E) Telephone ear deformity
The correct response is Option C.
While there are a number of successful methods to perform a facelift, there are certainly common principles they share. These include:
Making an artfully placed incision which follows anatomic contours
Skin elevation to allow access to the superficial musculoaponeurotic system (SMAS) and release of any tethered points of the facial skin following SMAS manipulation
Some method (elevation, plication, imbrication, or direct suturing) of tightening the mobile SMAS
Anchoring of the SMAS in its new position with some stable method of fixation
Re-draping the soft-tissues using appropriate vectors
Careful skin closure where minimal tension is placed on the earlobe and posterior hairline incision
Placement of significant tension on the earlobe caused by excessive trimming of the skin flap in the region of the otobasion inferius is well known to commonly produce a distinctive postoperative distortion of this structure, also known as a “pixie ear.” The study by Mowlavi and associates showed an incidence of approximately 6% in a facelift population.
A tension-free closure of the earlobe to the skin flap should be the goal, avoiding tension on the delicate earlobe tissues from the cheek flap, to avoid the issue of inferior and anterior migration of the otobasion. A number of corrective techniques have been described, ranging from local V-Y closures to readvancement of the facelift flap. Earlobe ptosis, in which the vertical height of the earlobe increases with aging, is unchanged by skin trimming errors. Telephone and reverse telephone deformities are complications in otoplasty for prominent ears, and do not apply to this case. Lop ear deformity is a congenital ear deformity involving the superior portion of the helix, and is not relevant to this case.
An otherwise healthy 55-year-old woman with Fitzpatrick Type II skin desires facial rejuvenation. Phenol-croton oil (Hetter) peel with simultaneous extended superficial musculoaponeurotic system rhytidectomy and transconjunctival lower blepharoplasty is planned. Which of the following anatomic areas is at greatest risk for healing complications after this procedure?
A) Forehead
B) Lateral cheek
C) Lower eyelid
D) Nasal dorsum
E) Perioral
The correct response is Option B.
In general, non-undermined skin can be safely peeled at the time of a facelift. So the “T-zone” of forehead, nose, and perioral and labiomandibular fold areas are not at increased risk for resurfacing during a facelift.
Undermined skin, particularly when flaps are thin, is risky for delayed wound healing and scarring with concurrent peeling. Peeling of the thin preauricular flap, raised during the facelift, would be the most risky of the choices listed.
Zins and associates showed that croton oil peeling was safe and effective in a series of patients with simultaneous lower eyelid surgery, including both transconjunctival blepharoplasty and the pinch technique of skin excision. Again, the peel was not performed on areas of skin undermining.
A 55-year-old man is scheduled for a rhytidectomy with an extended superficial musculoaponeurotic system (SMAS) flap and neck lift. In order to avoid injury to the great auricular nerve, which of the following best describes the most likely course of the main branch of the great auricular nerve?
A) Exits the deep neck at the anterior border of the sternocleidomastoid muscle
B) Exits the stylomastoid foramen and emerges through the Lore fascia
C) Lies parallel and posterior to the external jugular vein
D) Lies superficial to the platysma muscle at the anterior border of the sternocleidomastoid muscle
E) Perforates the sternocleidomastoid muscle 6.5 cm inferior to the external auditory meatus
The correct response is Option C.
The great auricular nerve (GAN) is the most commonly injured named nerve during a rhytidectomy. Multiple studies have estimated the incidence at 6%. The course and avoidance of injury to this nerve is important in minimizing the risks for painful neuroma, allodynia, and permanent numbness. The GAN is a purely sensory nerve that arises from the C2 and C3 spinal roots and then fuses into the main trunk of the GAN. It exits the deep neck along the posterior border of the sternocleidomastoid muscle (SCM) and then travels parallel and posterior to the external jugular vein (EJV). It usually bifurcates into anterior and posterior branches. There are anomalous courses that can occur in rare cases.
Guidelines in avoiding injury of the GAN include the following:
Raising the platysma at the anterior border of the SCM will protect the nerve from injury.
To avoid suture injury to the nerve, platysma/superficial musculoaponeurotic system suspension sutures should be placed posterior to a vertical line drawn from McKinney’s point to a point 1.5 cm posterior to the insertion of the lobule.
The GAN does not perforate the SCM, but lies on top of it. McKinney’s point is located along the midwidth of the SCM approximately 6.5 cm inferior to the external auditory meatus. This represents where the GAN usually exits from beneath the SCM fascia and becomes more superficial and is increasingly susceptible to injury.
At the sternocleidomastoid muscle, the GAN lies deep to the platysma muscle and is a safe location to begin elevation of a platysma flap.
The facial nerve exits the stylomastoid foramen, not the GAN.
A 58-year-old woman comes to the office because of muscle weakness of the lower face after undergoing rhytidectomy. Which of the following findings is most likely to indicate an injury to the cervical branch facial nerve in this patient, rather than the marginal mandibular nerve?
A) The patient can still purse her lips
B) The patient has lower lip depression weakness
C) The patient has lower lip numbness
D) The patient has mid-facial weakness
E) The patient has upper lip numbness
The correct response is Option A.
In a cervical branch facial nerve injury, lip depression can be weak, but the mentalis and orbicularis oris innervation remain intact, so that the patient would be able to purse her lips. Neither the cervical nor marginal mandibular nerves provide sensation to the lip. It would not be necessary to obtain a nerve conduction study in this case, because physical examination would be enough to distinguish between injuries to these nerves. The mid-face motor nerves would not be involved.
A 27-year-old woman comes to the office with concerns about aesthetic deformity of the neck. Despite appropriate lifestyle modifications and BMI less than 25 kg/m2, the patient has an obtuse cervicomental angle caused by accumulation of preplatysmal adipose tissue. The patient opts for nonsurgical management of the submental fullness by undergoing treatment with deoxycholic acid (DCA). Which of the following best describes the mechanism of action of this agent?
A) Disruption of cellular membrane
B) Injury to endoplasmic reticulum
C) Irreversible binding to cellular mitochondrion
D) Protein binding of Golgi apparatus
E) Targeted injury to cell nucleus
The correct response is Option A.
Deoxycholic acid (DCA) disrupts adipocyte cell membranes when injected subcutaneously into fat, inducing an inflammatory response to clear cellular debris and liberated lipids from the injection site. DCA is a nonspecific cytolytic agent that injures tissue by injuring the cellular membrane of cells that come into contact with the naturally found substance. ATX-101 was FDA approved in the United States and Canada in 2015 for treatment of patients diagnosed with moderate to severe amounts of fat accumulating in the submental fat pad. The treatment is a series/protocol of up to six treatments in patients requesting nonsurgical management of submental fullness. Patients are selected based on candidacy and their desire to avoid surgery. A youthful patient with mild to no skin laxity, minimal post-platysmal fat, mild to no digastric muscle hypertrophy, and minimally enlarged submandibular glands is a good candidate for the treatment.
Mitochondria, responsible for energy metabolism within the cell, act as signaling organelles. Mitochondrial dysfunction may lead to cell death and oxidative stress and may disturb calcium metabolism. The nucleus is the control center of the eukaryotic cell. The sequestering of genetic material within the nucleus of the eukaryotic cell provides the nucleus with a powerful mechanism for the regulation of gene expression and other cellular processes through selective translocation of proteins between the nucleus and cytoplasm. There are various drugs that act on DNA to prevent its replication and to decrease or inhibit transcription of a variety of important genes. However, a therapeutic molecule, even if delivered inside the target cell, often fails to reach its subcellular target. The Golgi apparatus (GA) is the central organelle of the cell secretory pathway and interacts with the endoplasmic reticulum (ER). The GA carries out posttranslational modification of newly synthesized proteins by employing various enzymes for phosphorylation, acylation, glycosylation, methylation, and sulfation. The ER is a network of folded membrane-enclosed tubules and sacs (cisternae) that extend from the nuclear membrane throughout the cytoplasm. Its primary function is to facilitate the folding of secretory and membrane proteins. Additionally, it is involved in calcium storage and signaling, and has been shown to play a role in apoptosis regulation against disturbances in calcium homeostasis, ischemia, hypoxia, exposure to free radicals, oxidative stress, elevated protein synthesis, and gene mutations. Several different types of drugs target these organelles, but these cellular components are not the target of deoxycholic acid.
A 65-year-old woman comes to the office for consultation regarding facial rejuvenation. She is bothered by deepened nasolabial folds and what she describes as a “hollowness” of her cheeks. Which of the following factors is most important in the development of this patient’s facial aging?
A) Atrophy of the periosteal lining and its effects on the facial bones
B) Deflation of facial fat compartments and attenuation of facial retaining ligaments
C) Increased collagen deposition leading to facial skin changes
D) Loss of tone and volume of the underlying mimetic musculature
The correct response is Option B.
A significant factor that leads to the classic signs of facial aging is the loss of volume, or deflation of the fat compartments of the face in conjunction with attenuation and laxity of the anatomical retaining ligaments of the face, which compartmentalize the fat compartments. These two factors in concert lead to the classic appearance associated with facial aging and the associated description of volume loss and descent of the soft tissues of the face.
It is important to note that facial aging is influenced by both environmental, as well as anatomical factors. Controllable environmental factors, such as smoking, excessive alcohol consumption, extremes of BMI, and excessive unprotected sun exposure, can influence and even accelerate the aging process, but even without the presence of these factors, facial aging will occur due to anatomical changes.
Skeletal changes that occur with age influence the way in which the face appears over time. Numerous studies have evaluated changes in the bones of the orbits, mid face, and mandible and their effects on facial appearance. Not only does the bone structure change and influence appearance, but the effects of these skeletal changes also affect the appearance of the overlying skin and soft tissues, thus having a secondary effect. It is the actual change in facial bone shape, not the overlying periosteum, that causes these age-related changes in facial appearance.
Along with changes under the skin, so too does the skin change during the aging process. Chronic photodamage to the skin results in pigmentary changes as well as epidermal thinning. Dermal changes occur, including collagen disruption as well as collagen loss and increased elastin production.
Utilizing MRI, Gosain et al. disproved the once held notion that loss of volume of the underlying mimetic musculature and atrophy of the periosteum led to facial aging—related volume loss.
Pessa and Rohrich have shown that the retaining ligaments of the face help to compartmentalize the fat compartments of the face. As these fat compartments atrophy over time, one notices facial volume loss. In conjunction with this volume loss, as the retaining ligaments become attenuated, this leads to descent of the fat compartments, which leads to the appearance of skin laxity and deepened folds in specific anatomical sites, such as the nasolabial fold, tear trough, and jowl.
A 55-year-old woman has pain and weakness of the shoulder, and inability to lift her shoulder girdle 2 weeks after undergoing rhytidectomy, advancement of an extended superficial musculoaponeurotic system flap, and plication of the platysma with complete transection. A nerve injury is suspected. During which of the following parts of the rhytidectomy was the nerve most likely injured?
A) Anchoring the superficial musculoaponeurotic system flap to Lore fascia
B) Dissection of the lateral neck
C) Flap elevation at McKinney point
D) Subplatysmal fat resection
E) Transection of the platysma
The correct response is Option B.
This patient’s symptoms relate to an injury to the spinal accessory nerve (cranial nerve XI). This nerve innervates the sternocleidomastoid and the trapezius muscles. The spinal accessory nerve exits the cranium through the jugular foramen. It then passes deep to the styloid process and under the sternocleidomastoid muscle. The nerve exits the posterior border of the sternocleidomastoid fascia within 2 cm superior to the great auricular nerve. After it exits the muscle, the nerve is vulnerable to injury because it is tightly sandwiched between the skin and the muscle fascia. It then runs obliquely and inferiorly to the anterior edge of the trapezius muscle. The course of the spinal accessory nerve usually follows a path drawn by a line perpendicular to and bisecting a line connecting the angle of the mandible and the tip of the mastoid process.
Lore fascia is a dense tissue inferior to the auricle that can be used to anchor the superficial musculoaponeurotic system fascia. The facial nerve is 2.5 cm deep to this fascia. McKinney point is where the great auricular nerve consistently crosses the mid transverse belly of the sternocleidomastoid muscle approximately 6.5 cm below the caudal edge of the bony external auditory canal. The spinal accessory nerve is posterior to the platysma.
A 56-year-old woman has prominent glabellar rhytids and says that her eyelids appear “heavy.” On examination, the patient has a high hair line and relatively thin hair; the eyebrows are positioned just inferior to the supraorbital rims laterally. There is mild redundancy of the upper eyelid skin. Which of the following is the most appropriate management?
A) Carbon dioxide laser resurfacing of the forehead and upper eyelid blepharoplasty
B) Open browlifting through a coronal incision, including resection of the corrugator and procerus muscles
C) Open browlifting through a hairline incision, including resection of the corrugator and procerus muscles
D) Upper eyelid blepharoplasty
E) Upper eyelid blepharoplasty and injection of botulinum toxin (Botox) into the glabellar region
Correct answer is option C.
The most appropriate management in this patient with “heavy” appearing eyes is open browlifting through a hairline incision, including resection of the corrugator and procerus muscles. Open browlifting will decrease the height of the forehead, and the incision can be hidden beneath the hair. Concomitant resection of the corrugator and procerus muscles will improve the glabellar rhytids. Laser resurfacing is effective for treatment of rhytids but not eyebrow ptosis. A coronal approach, which involves resection of skin posterior to the hair line, will actually lengthen the forehead and leave an unsightly scar in a patient with thinning hair. Upper eyelid blepharoplasty will not improve eyebrow ptosis. Injection of botulinum toxin will provide only temporary improvement of the glabellar rhytids.
A 50-year-old woman comes to the office because she is unhappy with the lax appearance of her neck (shown) after massive weight loss. Which of the following is the most appropriate management?
A) Dermabrasion
B) Fat grafting
C) Laser treatment
D) Rhytidectomy
E) Suction lipectomy

The correct response is Option D.
Massive weight loss results in loss of soft-tissue volume with ptosis, increased laxity, and redundant skin of the face. Many patients present with advanced aging in the face because changes subsequent to massive weight loss mimic aging.
Dermabrasion is a technique used to treat fine rhytides and irregular surface of the facial skin, such as those associated with chronic acne scarring. Laser treatments tighten skin but do not add volume. Both of these modalities have no applicability to neck rejuvenation and may cause irreversible scarring of the neck.
Fat grafting may help fill the depressed nasolabial and perioral folds but does not help to tighten skin or treat platysmal bands. Rhytidectomy with upward suspension of the superficial musculoaponeurotic system and platysma, along with reduction of skin laxity, is the only valid procedure to treat the manifestations of massive weight loss illustrated in the patient described.
Suction lipectomy will only exacerbate complications of decreasing soft-tissue fullness and will have little to no effect on skin tightening.


