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Infectious Agents > Exam 4: Moraxellaceae, Pseudomonadaceae, Bordetella > Flashcards

Exam 4: Moraxellaceae, Pseudomonadaceae, Bordetella Flashcards

1
Q

What is the pathogenic species of veterinary importance in the family Moraxellaceae?

A

M. bovis

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2
Q

What does M. bovis cause?

A

Infectious bovine keratoconjunctivitis or “pinkeye” in cattle

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3
Q

What is M. bovis a commensal organism of?

A

Nasopharynx and conjunctiva of cattle

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4
Q

What is the pathogenesis of M. bovis?

A

Type 4 fimbriae mediate adherence and colonization to corneal and conjunctival epithelial cells

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5
Q

What is require for the virulence of M/ bovis?

A

RTX cytotoxin

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6
Q

What can M. bovis be isolated on and what does it produce?

A

Blood agar and it produces a narrow zone of beta hemolysis

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7
Q

What is used to treat pinkeye in cattle?

A

Oxytetracycline and florfenicol

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8
Q

What should be done in outbreak situations of M. bovis?

A

Add chloretetracycline to feed for at least 30 days

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9
Q

What family is considered to be the ultimate opportunist?

A

Pseudomonadaceae, more specifically P. aeruginosa

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10
Q

What does P. aeruginosa produce?

A

Pyocyanin, a green pigment that reacts with oxygen to form toxic radicals

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11
Q

What does P. aeurginosa almost always depend on to cause disease?

A

A defect in normal host defense mechanisms

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12
Q

What is P. aeurginosa a common cause of?

A

Wound abscesses, UTI infections, and eye infections

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13
Q

Why is the pathogenesis of P. aeuroginosa complex?

A

Because the organism is invasive, toxinogeic, and endowed with multiple virulence factors

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14
Q

What are the virulence factors of P. aeuroginosa?

A 
Surface slime
Type 3 secretion system
Proteases
Fimbriae
Antimicrobial resistance
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15
Q

What is bordetella parasites of?

A

Ciliated respiratory epithelium

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16
Q

What is B. bronchiseptica a commensal of?

A

URT of dogs, cats, swine, rabbits, and other animals

17
Q

What is B. bronchiseptica the most common cause of?

A

Respiratory infection in guinea pigs

18
Q

What is BvgAS?

A

A sensory system that detects environmental signal and turns on virulence genes
Virulence factor of regulation for B. bronchiseptica

19
Q

What are the adhesins that are virulence factors for B. bronchiseptica?

A

Filamentous hemagglutinin
Fimbriae
Pertactin

20
Q

What are the exotoxins that are a virulence factor for B. bronchiseptica?

A

Adenylate cyclase
Dermonecrotic toxin
Pertussis toixn

21
Q

What does adenylate cyclase do?

A

Inhibits phagocytic activity

22
Q

What is the pathogenesis of B. bronchiseptica?

A

Attaches to ciliated respiratory epithelium
Increased cAMP cuases increased mucus production and fluid accumulation
Ciliary paralysis occurs due to increased cAMP
Ciliated respiratory epithelial cells are killed by T3SS
Loss of ciliary function and death of ciliated epithelial cells
Bordetella adheres to recruited phagocytes and phagocytosis is inhibited by increased cAMP

23
Q

What is the transmission of B. bronchiseptica?

A

Inhalation
Endogenous or exogenous
Direct or indirect contact and fomites

24
Q

What does B. bronchiseptica cause in dogs?

A

Infectious tracheobronchitis

25
Q

What is natural disease with B. bronchiseptica often accompanied by in dogs?

A

Canine parainfluenza virus 2 or canine adenovirus 1 or 2

26
Q

What does B. bronchiseptica cause in swine?

A

Upper respiratory tract infection at 3-4 weeks of age

Atrophic rhinitis

27
Q

What does B. bronchiseptica cause in lab animals?

A

Pneumonia and URT infections

28
Q

What does B. bronchiseptica cause in cat colonies?

A

Mild URT infections

29
Q

What does B. bronchiseptica cause in guinea pigs?

A

Catarrhal to mucopurulent exudates in the upper respiratory tract

Infectious Agents (38 decks)

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