Exam 3: E. coli Enteric Diseases

Question 1

What is the host association for F4?

Answer 1

Swine ETEC

Question 2

What is the host association for F5?

Answer 2

Cattle, sheep, and swine ETEC

Question 3

What is the host association for F6?

Answer 3

Almost always association with swine ETEC, sometimes cattle

Question 4

What is the host association for F18?

Answer 4

It is now a common fimbrial adhesion associated with swine ETEC

Question 5

What is F18ab primarily associated with?

Answer 5

Edema disease strains

Question 6

What is F18ac primarily associated with?

Answer 6

ETEC

Question 7

What is the host association for F41?

Answer 7

Usually with cattle, sometimes swine

Question 8

What does diarrhea result from?

Answer 8

Action of enterotoxins

Question 9

What is LT involved with?

Answer 9

The swine type of E. coli

Question 10

What is LT?

Answer 10

Heat-labile

A large protein made up of A and B subunits

Question 11

What is the general mechanism of LT?

Answer 11

It causes disregulation of adenylate cyclase, which causes overproduction of cAMP

Question 12

What is LT1?

Answer 12

Plasmid encoded and neutralized by anti-cholera toxin antibodies

Question 13

What is LT2?

Answer 13

Chromosomoally encoded and not neutralized by anti-cholera toxin antibodies

Question 14

What is heat stable (ST)?

Answer 14

A family of low MW proteins with a lipoprotein binding portion

Question 15

What does STa do?

Answer 15

Activates guanylate cyclase and causes overproduction of cGMP

Question 16

What does STb do?

Answer 16

Stimulates a GTP-binding regulatory protein

Question 17

What is produced with porcine ETEC?

Answer 17

STa and/or STb

Question 18

What is produced with bovine ETEC?

Answer 18

STa

Question 19

Describe EAEC

Answer 19

Associated with disease and can cause watery diarrhea

Question 20

What do some EAEC express?

Answer 20

EAST1 toxin

Question 21

What can E. coli expressing EAST1 or AAF be isolated from?

Answer 21

Weaned pigs with diarrhea and calves with diarrhea

Question 22

What does human EPEC express?

Answer 22

Fimbriae called bundle forming pili

Question 23

What is intimate adherence caused by in EPEC?

Answer 23

Intimin

Question 24

What does EPEC have?

Answer 24

Type III secretion system

Question 25

What is one of the injected proteins in EPEC?

Answer 25

Tir

Question 26

What do tir and other injected proteins do in EPEC?

Answer 26

Reorganize the actin cytoskeleton in enterocytes to form attaching and effacing lesions

Question 27

What is EPEC a major cause of in young rabbits?

Answer 27

Diarrhea

Question 28

What is the target of shiga toxin?

Answer 28

Endothelial cells

Question 29

What does shiga toxin do to endothelial cells?

Answer 29

Shuts down protein translation/synthesis

Question 30

What does EHEC/STEC?

Answer 30

Shiga toxin, unlike EPEC

Question 31

Describe the shiga toxin Stx2e

Answer 31

Associated with edema disease in swine

Question 32

Which E. coli use T3SS as the mechanism of producing disease?

Answer 32

Enteropathogenic and enterohemorrhagic