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Infectious Agents > Exam 3: E. coli Enteric Diseases > Flashcards

Exam 3: E. coli Enteric Diseases Flashcards

1
Q

What is the host association for F4?

A

Swine ETEC

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2
Q

What is the host association for F5?

A

Cattle, sheep, and swine ETEC

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3
Q

What is the host association for F6?

A

Almost always association with swine ETEC, sometimes cattle

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4
Q

What is the host association for F18?

A

It is now a common fimbrial adhesion associated with swine ETEC

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5
Q

What is F18ab primarily associated with?

A

Edema disease strains

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6
Q

What is F18ac primarily associated with?

A

ETEC

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7
Q

What is the host association for F41?

A

Usually with cattle, sometimes swine

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8
Q

What does diarrhea result from?

A

Action of enterotoxins

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9
Q

What is LT involved with?

A

The swine type of E. coli

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10
Q

What is LT?

A

Heat-labile

A large protein made up of A and B subunits

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11
Q

What is the general mechanism of LT?

A

It causes disregulation of adenylate cyclase, which causes overproduction of cAMP

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12
Q

What is LT1?

A

Plasmid encoded and neutralized by anti-cholera toxin antibodies

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13
Q

What is LT2?

A

Chromosomoally encoded and not neutralized by anti-cholera toxin antibodies

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14
Q

What is heat stable (ST)?

A

A family of low MW proteins with a lipoprotein binding portion

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15
Q

What does STa do?

A

Activates guanylate cyclase and causes overproduction of cGMP

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16
Q

What does STb do?

A

Stimulates a GTP-binding regulatory protein

17
Q

What is produced with porcine ETEC?

A

STa and/or STb

18
Q

What is produced with bovine ETEC?

A

STa

19
Q

Describe EAEC

A

Associated with disease and can cause watery diarrhea

20
Q

What do some EAEC express?

A

EAST1 toxin

21
Q

What can E. coli expressing EAST1 or AAF be isolated from?

A

Weaned pigs with diarrhea and calves with diarrhea

22
Q

What does human EPEC express?

A

Fimbriae called bundle forming pili

23
Q

What is intimate adherence caused by in EPEC?

A

Intimin

24
Q

What does EPEC have?

A

Type III secretion system

25
Q

What is one of the injected proteins in EPEC?

A

Tir

26
Q

What do tir and other injected proteins do in EPEC?

A

Reorganize the actin cytoskeleton in enterocytes to form attaching and effacing lesions

27
Q

What is EPEC a major cause of in young rabbits?

A

Diarrhea

28
Q

What is the target of shiga toxin?

A

Endothelial cells

29
Q

What does shiga toxin do to endothelial cells?

A

Shuts down protein translation/synthesis

30
Q

What does EHEC/STEC?

A

Shiga toxin, unlike EPEC

31
Q

Describe the shiga toxin Stx2e

A

Associated with edema disease in swine

32
Q

Which E. coli use T3SS as the mechanism of producing disease?

A

Enteropathogenic and enterohemorrhagic

Infectious Agents (38 decks)

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