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Infectious Agents > Exam 4: Brucella and Bartonella > Flashcards

Exam 4: Brucella and Bartonella Flashcards

1
Q

What species does Brucella abortus prefer?

A

Cattle

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2
Q

What species does B. suis prefer?

A

Swine

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3
Q

What species does B. melitensis prefer?

A

Goats and sheep

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4
Q

What species does B. ovis prefer?

A

Sheep

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5
Q

What species does B. canis prefer?

A

Dogs

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6
Q

Which of the Brucella species is the most zoonotic?

A

B. melitensis

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7
Q

What is the transmission of Brucella?

A

Ingestion is the most common, but exposure through conjunctival and genital mucosa and respiratory routes occurs

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8
Q

What is the major source for exposure to B. abortus and B. melitensis?

A

Through aborted fetuses, the placenta, and postabortion uterine fluids

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9
Q

What can vertical transmission of B. melitensis and B. abortus occur through?

A

Infected milk

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10
Q

What allow for the veneral transmission of B. suis, B. ovis, and B. canis in males?

A

Infection of accessory sex glands

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11
Q

What can B. canis and B. suis be transmitted through?

A

Urine or milk

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12
Q

What can Brucella penetrate?

A

Intact mucosa

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13
Q

Where does Brucella localize?

A

Regional lymph nodes, where it either proliferates or is killed

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14
Q

Why do females abort with Brucella?

A

Probably due to acquired immunity

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15
Q

What diseases does Brucella cause in males?

A

Epididymitis, orchitis, usually unilateral

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16
Q

What is the order of virulence, most to least, of Brucella species in humans?

A

B. melitensis
B. suis
B. abortus
B. canis

17
Q

How is Brucellla an occupational risk?

A

Exposure to aborted fetuses/placentas
B. suis: prolonged bacteremic phase poses risk in slaughterhouse
Hunting feral swine
Kennel workers, but B. canis infection in humans is rare
Contaminated raw milk from infected cows or goats

18
Q

How can Brucella be diagnosed?

A

Culturing from abscess, semen, or vaginal fluids
Antibody can confirm isolates
DNA detection by PCR
Serum antibody detection

19
Q

What does Bartonella henselae cause?

A

Cat scratch disease in humans

Infection in cats

20
Q

What does Bartonella vinsonii cause?

A

Endocarditis/myocarditis in humans

21
Q

What does Bartonella vinsonii subspecies berhoffi cause?

A

Canine endocarditis

22
Q

What is the transmission of Bartonella?

A

Most are vector-borne

23
Q

What do Bartonella species multiply and persist in?

A

Erythrocytes

24
Q

What does Bartonella often induce?

A

Endothelial proliferation

25
Q

What does B. henselae induce?

A

Infected cells to produce vascular endothelial growth factor

Infectious Agents (38 decks)

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