ESR [038] Implantation, pregnancy and Lactation Flashcards
Explain
Role of Progesterone in pregnancy ?
-Maintains the uterine endometrium
-Inhibits contractility of the uterine myometrium
- Inhibits uterine production of prostaglandins (PGs promote parturition)
Role of Oestrogen in pregnancy ?
-Stimulate uterine blood flow
-Fetal development
-Onset of parturition
-Development of breast for lactation
What does each line represent ?
during pregnancy ; Progesterone is synthesised by ….
Progesterone is synthesised by the placenta alone
during pregnancy ; Estrogen is synthesised by ….
The conceptus (placenta and fetus together) can produce estrogens
The predominant estrogen in pregnancy ?
Oestriol
explain
Where does the Conjugation of steroids to sulphates happen ?
Occurs in fetal liver and adrenals
Results of Conjugation of steroids to sulphates ?
• Makes the steroids biologically inert
Function of Conjugation of steroids to sulphates in the fetal liver ?
-Sulphation of steroids protects the fetus from high levels of steroids necessary during pregnancy
• Makes the steroids biologically inert
Requirements of Parturition ?
hormones involved in Parturition ?
Oxytocin and Prostaglandin F2a
Effect of stimulation of the cervix on endocrinal secretions ?
Secretes Oxytocin
Role of Oxytocin in the process of Parturition ?
causes contraction of the myometrium