[056], [057] Immunology of Endocrine Diseases-Aetiology & Pathogenesis

Question 1

Answer 1

Question 2

Physiological Role of HLA-DR gene ?

Answer 2

Question 3

Significance of CTLA-4 function in autoimmunity ?

Answer 3

Question 4

Answer 4

Question 5

Answer 5

Question 6

Gender prevalance of Graves’ disease ?

Answer 6

F:M = 7:1

Question 7

…..(auto immune pathol.) usually subsides during pregnancy, & rebounds post-partum

Answer 7

Thyroid autoimmunity

Question 8

the main destructive mechanism in Hashimoto’s disease ?

Answer 8

Cytotoxic T cell attack is probably the main destructive mechanism, with perhaps complement-fixing autoantibodies, NK cells and other immune mechanisms also playing a role

Question 9

Answer 9

Question 10

Role of Thyroid epithelial cells in Hashimoto’s disease ?

Answer 10

Thyroid epithelial cells (TECs) expressing MHC class II can present thyroid autoantigens to Th cells

Question 11

Pathogenesis of Graves’ opthalmopathy ?

Answer 11

Question 12

Answer 12

Question 13

Answer 13

Question 14

Answer 14

Question 15

Answer 15

Question 16

Answer 16

Question 17

In Type I diabetes , destruction is probably primarily by….. (Cells)

Answer 17

CD8 cytotoxic T lymphocytes.

Question 18

Pathogenisis of Addison’s disease ?

Answer 18

• Autoimmune attack on the adrenal gland

• Autoantibodies and T-cells against 21-hydroxylase

• Atrophy of adrenal gland, leading to deficient production of adrenocortical hormones

Question 19

Signs & Symptoms of Addison’s disease ?

Answer 19

• General malaise, fatigue, weakness, anorexia, nausea, vomiting, weight loss, hyperpigmentation, hypotension

Question 20

Answer 20