end of midterm 2 review Flashcards
repsonse time of innate immune repsone
mintues to hours
resonse time of adaptiev response
days
major cell types of innate resonse
phagocytes- monocytes, macrophages, neutrophils, dcs, NK cells
other leukocytes
epithelial and endothelial cells
what are the cell types of adaptive immunity
t cells
b cells
APCs
anatomical barriers to infection
enzymes and binding proteins
antimicrobial peptides
skin
acidic ph
ILCs
mirror t cells
there is three types of immunity
ILC1- similar to Th1
ILC2- similar to Th2
ILC3- similar to th17
TLR homologous to
fruit fly toll receptor
tLR recognition
variety of things hthroguh LRR extracellular dimers that recognize PAMPs and DAMPs
endosomal vs plasma TLR
endosomal recognize viral DNA and plasma rexognizes bacteria and fungi
plasma has TRIF w MyD88
endosomal activates IRFs
what does NFKB do
induces innate and inflammatory gene transcription
IFN function
feeds back to inhibit viral replication
what receptors function as phagocytic receptors
CLRs
what receptors are activates by intracellllar PAMPs and DAMPs
NLRs
NLRP3 inflammasome singla 1
TLR
CLR
NLR
singla 2 NLRP3 inflammasome
act through ROS to activate NEK7
leads to pyroptosis and activation of procytokines IL1 and il18 into thier mature forms
DIRA
deficiency of IL1 Receptor antagonist
DIRA treatment
kineret
human ILRA
what are rig i like receptors
RNA helicaes that recognize viral dsDNA
RIG i
major PRR of HCV infection
cgas
recognizes cytosolic DNA
activates STING
makes cGMP
sting
binds c-di-GMP bacterial metabolite
and activates NFKB and IRF
phagocytic macrophages
kuppfler cells- liver
microglial eclls- CNS
alveolar macrophages- lung
peritoneal macrophages- peritoneal fluid
phacocytic dc
Langerhand cells inthe skin and mucosa
what do phagocytes recognize microbes through
soluble proteins bound to microbes called opsonins thorugh opsonin receptors